Anti-PPIA Antibody (RACO0321)
- SKU:
- RACO0321
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- WB
- Application:
- ELISA
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| 商品名: | PPIA Antibody |
| Product SKU: | RACO0321 |
| サイズ: | 50ul |
| 宿主種: | Homo sapiens (Human) |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | WB:1:500-1:5000 |
| 反応性: | Human |
| 免疫原: | A synthesized peptide derived from human Cyclophilin A |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | Affinity-chromatography |
| 抗体のクローン性: | Monoclonal |
| アイソタイプ: | Rabbit IgG |
| Conjugate: | Non-conjugated |
| バックグラウンド: | PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. |
| シノニム: | Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed], PPIA, CYPA |
 | Western Blot. Positive WB detected in Raji whole cell lysate HepG2 whole cell lysate All lanes Cyclophilin A antibody at 1:1500. Secondary. Goat polyclonal to rabbit IgG at 1:50000 dilution. Predicted band size: 19, 12 kDa. Observed band size: 19 kDa. |
| UniProt Protein Function: | PPIA: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Interacts with HIV-1 Capsid protein. Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase. Belongs to the cyclophilin-type PPIase family. PPIase A subfamily. |
| UniProt Protein Details: | Protein type:Isomerase; RNA-binding; Cyclophilin; EC 5.2.1.8 Chromosomal Location of Human Ortholog: 7p13 Cellular Component: cytosol; extracellular region; extracellular space; focal adhesion; membrane; nucleus Molecular Function:peptidyl-prolyl cis-trans isomerase activity; protein binding; unfolded protein binding Biological Process: entry into host cell; leukocyte migration; positive regulation of protein secretion; positive regulation of viral genome replication; protein folding; protein peptidyl-prolyl isomerization; regulation of viral genome replication; release of virus from host; RNA-dependent DNA replication; uncoating of virus; viral envelope fusion with host membrane; viral infectious cycle; virus assembly |
| NCBI Summary: | This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P62937 |
| NCBI GenInfo Identifier: | 51702775 |
| NCBI Gene ID: | 5478 |
| NCBI Accession: | P62937.2 |
| UniProt Secondary Accession: | P62937,P05092, Q3KQW3, Q567Q0, Q6IBU5, Q96IX3, Q9BRU4 Q9BTY9, Q9UC61, A8K220, |
| UniProt Related Accession: | P62937 |
| Molecular Weight: | 11,418 Da |
| NCBI Full Name: | Peptidyl-prolyl cis-trans isomerase A |
| NCBI Synonym Full Names: | peptidylprolyl isomerase A |
| NCBI Official Symbol: | PPIA |
| NCBI Official Synonym Symbols: | CYPA; CYPH; HEL-S-69p |
| NCBI Protein Information: | peptidyl-prolyl cis-trans isomerase A |
| UniProt Protein Name: | Peptidyl-prolyl cis-trans isomerase A |
| UniProt Synonym Protein Names: | Cyclophilin A; Cyclosporin A-binding protein; Rotamase A |
| Protein Family: | Peptidyl-prolyl cis-trans isomerase |
| UniProt Gene Name: | PPIA |
| UniProt Entry Name: | PPIA_HUMAN |