Anti-PITX1 Antibody (CAB4022)
- SKU:
- CAB4022
- Product type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-PITX1 Antibody |
| 抗体コード: | CAB4022 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human PITX1 (NP_002644.4). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Rat |
| ポジティブサンプル: | Rat pancreas |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human PITX1 (NP_002644.4). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MDAF KGGM SLER LPEG LRPP PPPP HDMG PAFH LARP ADPR EPLE NSAS ESSD TELP EKER GGEP KGPE DSGA GGTG CGGA |
| 遺伝子ID: | 5307 |
| Uniprot: | P78337 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 34kDa |
| 観察された分子量: | 40kDa |
| 同義語: | PITX1, BFT, CCF, LBNBG, POTX, PTX1 |
| バックグラウンド: | This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. |
| UniProt Protein Function: | PITX1: May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. Defects in PITX1 are a cause of congenital clubfoot (CCF); also known as talipes equinovarus (TEV). Clubfoot is a congenital limb deformity defined as fixation of the foot in cavus, adductus, varus, and equinus (i.e. inclined inwards, axially rotated outwards, and pointing downwards) with concomitant soft tissue abnormalities. Clubfoot may occur in isolation or as part of a syndrome. Clubfoot appears to be a multifactorial trait. Belongs to the paired homeobox family. Bicoid subfamily. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 5q31.1 Cellular Component: nucleolus; nucleus Molecular Function:protein binding Biological Process: anatomical structure morphogenesis; skeletal development Disease: Clubfoot, Congenital, With Or Without Deficiency Of Long Bones And/or Mirror-image Polydactyly; Liebenberg Syndrome |
| NCBI Summary: | This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P78337 |
| NCBI GenInfo Identifier: | 108935922 |
| NCBI Gene ID: | 5307 |
| NCBI Accession: | P78337.2 |
| UniProt Secondary Accession: | P78337,O14677, O60425, Q9BTI5, A8K3M0, D3DQB0, |
| UniProt Related Accession: | P78337 |
| Molecular Weight: | 34,128 Da |
| NCBI Full Name: | Pituitary homeobox 1 |
| NCBI Synonym Full Names: | paired like homeodomain 1 |
| NCBI Official Symbol: | PITX1 |
| NCBI Official Synonym Symbols: | BFT; CCF; POTX; PTX1; LBNBG |
| NCBI Protein Information: | pituitary homeobox 1 |
| UniProt Protein Name: | Pituitary homeobox 1 |
| UniProt Synonym Protein Names: | Hindlimb-expressed homeobox protein backfoot; Homeobox protein PITX1; Paired-like homeodomain transcription factor 1 |
| Protein Family: | Pituitary homeobox |
| UniProt Gene Name: | PITX1 |
| UniProt Entry Name: | PITX1_HUMAN |
 | Western blot analysis of extracts of rat pancreas, using PITX1 antibody (CAB4022) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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