| バックグラウンド: | This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014] |
| UniProt Protein Function: | PRDX3: Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical- generating system. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. Belongs to the AhpC/TSA family. |
| UniProt Protein Details: | Protein type:Oxidoreductase; EC 1.11.1.15 Chromosomal Location of Human Ortholog: 10q25-q26 Cellular Component: mitochondrion; mitochondrial matrix; cytoplasm; early endosome; IkappaB kinase complex; cytosol Molecular Function:protein C-terminus binding; identical protein binding; protein binding; thioredoxin peroxidase activity; caspase inhibitor activity; alkyl hydroperoxide reductase activity; kinase binding; protein kinase binding Biological Process: negative regulation of kinase activity; mitochondrion organization and biogenesis; response to lipopolysaccharide; negative regulation of caspase activity; activation of NF-kappaB transcription factor; response to reactive oxygen species; peptidyl-cysteine oxidation; response to hydrogen peroxide; regulation of mitochondrial membrane potential; hydrogen peroxide catabolic process; positive regulation of cell proliferation; myeloid cell differentiation; response to oxidative stress; negative regulation of apoptosis; maternal placenta development |
| NCBI Summary: | This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014] |
| UniProt Code: | P30048 |
| NCBI GenInfo Identifier: | 2507171 |
| NCBI Gene ID: | 10935 |
| NCBI Accession: | P30048.3 |
| UniProt Related Accession: | P30048 |
| Molecular Weight: | 26kDa |
| NCBI Full Name: | Thioredoxin-dependent peroxide reductase, mitochondrial |
| NCBI Synonym Full Names: | peroxiredoxin 3 |
| NCBI Official Symbol: | PRDX3 |
| NCBI Official Synonym Symbols: | AOP1; MER5; AOP-1; SP-22; HBC189; PRO1748; prx-III |
| NCBI Protein Information: | thioredoxin-dependent peroxide reductase, mitochondrial |
| UniProt Protein Name: | Thioredoxin-dependent peroxide reductase, mitochondrial |
| UniProt Synonym Protein Names: | Antioxidant protein 1; AOP-1; HBC189; Peroxiredoxin III; Prx-III; Peroxiredoxin-3; Protein MER5 homolog |
| UniProt Gene Name: | PRDX3 |
| UniProt Entry Name: | PRDX3_HUMAN |
