Anti-PDE1B Antibody (CAB2102)
- SKU:
- CAB2102
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PDE1B Antibody |
| 抗体コード: | CAB2102 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 190-536 of human PDE1B (NP_000915.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | NCI-H460, THP-1, Mouse brain, Mouse spleen, Mouse spinal cord |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 190-536 of human PDE1B (NP_000915.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | RHNL ISRF KIPT VFLM SFLD ALET GYGK YKNP YHNQ IHAA DVTQ TVHC FLLR TGMV HCLS EIEL LAII FAAA IHDY EHTG TTNS FHIQ TKSE CAIV YNDR SVLE NHHI SSVF RLMQ DDEM NIFI NLTK DEFV ELRA LVIE MVLA TDMS CHFQ QVKT MKTA LQQL ERID KPKA LSLL LHAA DISH PTKQ WLVH SRWT KALM EEFF RQGD KEAE LGLP FSPL CDRT STLV AQSQ IGFI DFIV EPTF SVLT DVAE KSVQ PLAD EDSK SKNQ PSFQ WRQP SLDV EVGD PNPD VVSF RSTW VKRI QENK QKWK ERAA SGIT NQMS IDEL SPCE EEAP PSPA EDEH NQNG NLD |
| 遺伝子ID: | 5153 |
| Uniprot: | Q01064 |
| セルラーロケーション: | Cytoplasm |
| 計算された分子量: | 59kDa/61kDa |
| 観察された分子量: | 59kDa |
| 同義語: | PDE1B, HEL-S-79p, PDE1B1, PDES1B |
| バックグラウンド: | The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| UniProt Protein Function: | PDE1B: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate. Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.1.4.17; Nucleotide Metabolism - purine; Phosphodiesterase; Apoptosis Chromosomal Location of Human Ortholog: 12q13 Cellular Component: cell soma; cytosol Molecular Function:calmodulin binding; 3',5'-cyclic-AMP phosphodiesterase activity; calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; metal ion binding Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; monocyte differentiation; apoptosis; regulation of neurotransmitter levels; response to amphetamine; cAMP catabolic process; regulation of dopamine metabolic process; locomotory behavior; signal transduction; phospholipase C activation; innate immune response; visual learning; cGMP catabolic process; blood coagulation; serotonin metabolic process |
| NCBI Summary: | The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011] |
| UniProt Code: | Q01064 |
| NCBI GenInfo Identifier: | 3183514 |
| NCBI Gene ID: | 5153 |
| NCBI Accession: | Q01064.2 |
| UniProt Related Accession: | Q01064 |
| Molecular Weight: | 59kDa |
| NCBI Full Name: | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B |
| NCBI Synonym Full Names: | phosphodiesterase 1B |
| NCBI Official Symbol: | PDE1B |
| NCBI Official Synonym Symbols: | PDE1B1; PDES1B; HEL-S-79p |
| NCBI Protein Information: | calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B |
| UniProt Protein Name: | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B |
| UniProt Synonym Protein Names: | 63 kDa Cam-PDE |
| UniProt Gene Name: | PDE1B |
| UniProt Entry Name: | PDE1B_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PDE1B antibody (CAB2102) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded rat brain using PDE1B antibody (CAB2102) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of U2OS cells using PDE1B antibody (CAB2102). Blue: DAPI for nuclear staining. |
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