| UniProt Protein Function: | Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism (PubMed:10364231, PubMed:28190768). This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:10364231). Mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity (PubMed:28190768). |
| NCBI Summary: | This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UGN5 |
| NCBI GenInfo Identifier: | 110825961 |
| NCBI Gene ID: | 10038 |
| NCBI Accession: | NP_005475 |
| UniProt Secondary Accession: | Q9UGN5,Q8TEU4, Q9NUV2, Q9UMR4, Q9Y6C8, |
| UniProt Related Accession: | Q9UGN5 |
| Molecular Weight: | 42.5 kDa (376aa) |
| NCBI Full Name: | poly |
| NCBI Synonym Full Names: | poly(ADP-ribose) polymerase 2 |
| NCBI Official Symbol: | PARP2 |
| NCBI Official Synonym Symbols: | ARTD2; ADPRT2; PARP-2; ADPRTL2; ADPRTL3; pADPRT-2 |
| NCBI Protein Information: | poly [ADP-ribose] polymerase 2 |
| UniProt Protein Name: | Poly [ADP-ribose] polymerase 2 |
| UniProt Synonym Protein Names: | ADP-ribosyltransferase diphtheria toxin-like 2; ARTD2; NAD(+) ADP-ribosyltransferase 2; ADPRT-2; Poly[ADP-ribose] synthase 2; pADPRT-2 |
| Protein Family: | Poly [ADP-ribose] polymerase |
| UniProt Gene Name: | PARP2 |
