Anti-PAK6 Antibody (CAB4871)
- SKU:
- CAB4871
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PAK6 Antibody |
| 抗体コード: | CAB4871 |
| 抗体サイズ: | 100µL |
| 申し込み: | WB IHC IF |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic Peptide of human PAK6 |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:1000 IHC 1:20 - 1:50 IF 1:20 - 1:50 |
| 反応性: | Human |
| ポジティブサンプル: | A-431 |
| 免疫原: | A synthetic Peptide of human PAK6 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 56924 |
| Uniprot: | Q9NQU5 |
| セルラーロケーション: | Cytoplasm, Nucleus |
| 計算された分子量: | 69kDa/74kDa |
| 観察された分子量: | 75kDa |
| 同義語: | PAK6, PAK5 |
| バックグラウンド: | This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | PAK6: a protein kinase of the STE20 family. Interacts with androgen receptor (AR), and cotranslocates into the nucleus with AR in response to androgen. Highly expressed in testis and prostate tissues. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Protein kinase, Ser/Thr (non-receptor); Protein kinase, STE; Kinase, protein; EC 2.7.11.1; STE group; STE20 family; PAKB subfamily Chromosomal Location of Human Ortholog: 15q14 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding; ATP binding; receptor signaling protein serine/threonine kinase activity Biological Process: regulation of transcription, DNA-dependent; apoptosis; cytoskeleton organization and biogenesis; mitotic cell cycle; protein amino acid phosphorylation |
| NCBI Summary: | This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013] |
| UniProt Code: | Q9NQU5 |
| NCBI GenInfo Identifier: | 23396789 |
| NCBI Gene ID: | 56924 |
| NCBI Accession: | Q9NQU5.1 |
| UniProt Secondary Accession: | Q9NQU5,A8K2G2, B3KYB0, G5E9R2, |
| UniProt Related Accession: | Q9NQU5 |
| Molecular Weight: | 681 |
| NCBI Full Name: | Serine/threonine-protein kinase PAK 6 |
| NCBI Synonym Full Names: | p21 protein (Cdc42/Rac)-activated kinase 6 |
| NCBI Official Symbol: | PAK6 |
| NCBI Official Synonym Symbols: | PAK5 |
| NCBI Protein Information: | serine/threonine-protein kinase PAK 6; p21(CDKN1A)-activated kinase 6 |
| UniProt Protein Name: | Serine/threonine-protein kinase PAK 6 |
| UniProt Synonym Protein Names: | PAK-5; p21-activated kinase 6; PAK-6 |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | PAK6 |
| UniProt Entry Name: | PAK6_HUMAN |
 | Western blot analysis of extracts of A-431 cells, using PAK6 antibody (CAB4871). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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