Anti-PAK4 Antibody (CAB2782)
- SKU:
- CAB2782
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Frequently bought together:
Description
| 抗体名: | Anti-PAK4 Antibody |
| 抗体コード: | CAB2782 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human PAK4 |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:1000 |
| 反応性: | Human |
| ポジティブサンプル: | 293T |
| 免疫原: | Recombinant protein of human PAK4 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 10298 |
| Uniprot: | O96013 |
| セルラーロケーション: | Cytoplasm |
| 計算された分子量: | 47kDa/48kDa/54kDa/64kDa |
| 観察された分子量: | 70KDa |
| 同義語: | PAK4 |
| バックグラウンド: | PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
| UniProt Protein Function: | PAK4: a protein kinase of the STE20 family. A mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Interacts specifically with the GTP-bound form of Cdc42 and weakly activates the JNK family of MAP kinases. Overexpressed in several cancers. Required for ras-dependent anchorage-independent growth of tumor cell lines. Four alternatively spliced human isoforms have been reported. |
| UniProt Protein Details: | Protein type:Kinase, protein; EC 2.7.11.1; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; PAKB subfamily Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: focal adhesion; Golgi apparatus Molecular Function:protein binding; receptor signaling protein serine/threonine kinase activity Biological Process: apoptosis; cell growth; cell migration; cell motility; cell proliferation; cytoskeleton organization and biogenesis; mitotic cell cycle; signal transduction |
| NCBI Summary: | PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O96013 |
| NCBI GenInfo Identifier: | 12585288 |
| NCBI Gene ID: | 10298 |
| NCBI Accession: | O96013.1 |
| UniProt Secondary Accession: | O96013,Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8, B4DGG6 |
| UniProt Related Accession: | O96013 |
| Molecular Weight: | |
| NCBI Full Name: | Serine/threonine-protein kinase PAK 4 |
| NCBI Synonym Full Names: | p21 (RAC1) activated kinase 4 |
| NCBI Official Symbol: | PAK4 |
| NCBI Protein Information: | serine/threonine-protein kinase PAK 4 |
| UniProt Protein Name: | Serine/threonine-protein kinase PAK 4 |
| UniProt Synonym Protein Names: | p21-activated kinase 4; PAK-4 |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | PAK4 |
| UniProt Entry Name: | PAK4_HUMAN |
 | Western blot analysis of extracts of 293T cells, using PAK4 antibody (CAB2782) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
View AllClose