Anti-NR2F2 Antibody (CAB10251)
- SKU:
- CAB10251
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-NR2F2 Antibody |
| 抗体コード: | CAB10251 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human NR2F2 (NP_066285.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | MCF7, 293T |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human NR2F2 (NP_066285.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAMV VSTW RDPQ DEVP GSQG SQAS QAPP VPGP PPGA PHTP QTPG QGGP ASTP AQTA AGGQ GGPG GPGS DKQQ QQQH IECV VCGD KSSG KHYG QFTC EGCK |
| 遺伝子ID: | 7026 |
| Uniprot: | P24468 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 29kDa/31kDa/45kDa |
| 観察された分子量: | 45kDa |
| 同義語: | NR2F2, ARP1, CHTD4, COUPTFB, COUPTFII, NF-E3, NR2F1, SVP40, TFCOUP2 |
| バックグラウンド: | This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | NR2F2: Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. Interacts with SQSTM1. Binds DNA as a dimer; homodimer or heterodimer with NR2F6. Interacts with NCOA1, NCOA2, NCOA3 and PPARGC1A. Interacts with ZFPM2. Ubiquitous. Belongs to the nuclear hormone receptor family. NR2 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor Chromosomal Location of Human Ortholog: 15q26.2 Cellular Component: nucleus Molecular Function:ligand-dependent nuclear receptor activity; protein binding; protein homodimerization activity; retinoic acid binding; sequence-specific DNA binding; transcription corepressor activity; transcription factor activity Biological Process: lipid metabolic process; negative regulation of cyclin-dependent protein kinase activity; negative regulation of endothelial cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter; signal transduction Disease: Congenital Heart Defects, Multiple Types, 4 |
| NCBI Summary: | This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] |
| UniProt Code: | P24468 |
| NCBI GenInfo Identifier: | 114203 |
| NCBI Gene ID: | 7026 |
| NCBI Accession: | P24468.1 |
| UniProt Secondary Accession: | P24468,Q03754, Q3KQR7, B4DQJ2, B6ZGU1, |
| UniProt Related Accession: | P24468 |
| Molecular Weight: | 46kDa |
| NCBI Full Name: | COUP transcription factor 2 |
| NCBI Synonym Full Names: | nuclear receptor subfamily 2 group F member 2 |
| NCBI Official Symbol: | NR2F2 |
| NCBI Official Synonym Symbols: | ARP1; CHTD4; NF-E3; NR2F1; SVP40; COUPTFB; TFCOUP2; COUPTFII |
| NCBI Protein Information: | COUP transcription factor 2 |
| UniProt Protein Name: | COUP transcription factor 2 |
| UniProt Synonym Protein Names: | Apolipoprotein A-I regulatory protein 1; ARP-1; COUP transcription factor II; COUP-TF II; Nuclear receptor subfamily 2 group F member 2 |
| Protein Family: | COUP transcription factor |
| UniProt Gene Name: | NR2F2 |
 | Western blot analysis of extracts of various cell lines, using NR2F2 antibody (CAB10251) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of U2OS cells using NR2F2 Rabbit pAb (CAB10251) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of L929 cells using NR2F2 Rabbit pAb (CAB10251) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of C6 cells using NR2F2 Rabbit pAb (CAB10251) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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