Anti-NR1H2 Antibody (CAB16291)
- SKU:
- CAB16291
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-NR1H2 Antibody |
| 抗体コード: | CAB16291 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human NR1H2 (NP_009052.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HepG2, A-431, SH-SY5Y, Mouse liver, Mouse brain, Rat liver |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human NR1H2 (NP_009052.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | KEAG MREQ CVLS EEQI RKKK IRKQ QQQE SQSQ SQSP VGPQ GSSS SASG PGAS PGGS EAGS QGSG EGEG VQLT AAQE LMIQ QLVA AQLQ CNKR SFSD QPKV T |
| 遺伝子ID: | 7376 |
| Uniprot: | P55055 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 39kDa/50kDa |
| 観察された分子量: | 51kDa |
| 同義語: | NR1H2, LXR-b, LXRB, NER, NER-I, RIP15, UNR |
| バックグラウンド: |
| UniProt Protein Function: | LXR-beta: Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Forms a heterodimer with RXR. Ubiquitous. Belongs to the nuclear hormone receptor family. NR1 subfamily. |
| UniProt Protein Details: | Protein type:Nuclear receptor Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: cytoplasm; nucleoplasm; nucleus Molecular Function:apolipoprotein A-I receptor binding; ATPase binding; DNA binding; protein binding Biological Process: negative regulation of lipid transport; negative regulation of pinocytosis; negative regulation of transcription, DNA-dependent; positive regulation of cellular protein metabolic process; positive regulation of cholesterol transport; positive regulation of fatty acid biosynthetic process; positive regulation of lipoprotein lipase activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; transcription initiation from RNA polymerase II promoter |
| NCBI Summary: | The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010] |
| UniProt Code: | P55055 |
| NCBI GenInfo Identifier: | 296439251 |
| NCBI Gene ID: | 7376 |
| NCBI Accession: | P55055.2 |
| UniProt Secondary Accession: | P55055,Q12970, Q5I0Y1, A8K490, B4DNM6, E7EWA6, |
| UniProt Related Accession: | P55055 |
| Molecular Weight: | 39,920 Da |
| NCBI Full Name: | Oxysterols receptor LXR-beta |
| NCBI Synonym Full Names: | nuclear receptor subfamily 1 group H member 2 |
| NCBI Official Symbol: | NR1H2 |
| NCBI Official Synonym Symbols: | NER; UNR; LXRB; LXR-b; NER-I; RIP15 |
| NCBI Protein Information: | oxysterols receptor LXR-beta |
| UniProt Protein Name: | Oxysterols receptor LXR-beta |
| UniProt Synonym Protein Names: | Liver X receptor beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; Ubiquitously-expressed nuclear receptor |
| Protein Family: | Oxysterols receptor |
| UniProt Gene Name: | NR1H2 |
| UniProt Entry Name: | NR1H2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NR1H2 antibody (CAB16291) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3min. |
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