Anti-NPB Antibody (CAB16612)

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SKU:
CAB16612
Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
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Description

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抗体名:Anti-NPB Antibody
抗体コード:CAB16612
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB IF
反応性:Human, Mouse
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-125 of human NPB (NP_683694.1).
申し込み:WB IF
推奨希釈:WB 1:500 - 1:2000 IF 1:50 - 1:200
反応性:Human, Mouse
ポジティブサンプル:SW480, Mouse brain
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-125 of human NPB (NP_683694.1).
精製方法:Affinity purification
ストレージバッファ:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:MARS ATLA AAAL ALCL LLAP PGLA WYKP AAGH SSYS VGRA AGLL SGLR RSPY ARRS QPYR GAEP PGGA GASP ELQL HPRL RSLA VCVQ DVAP NLQR CERL PDGR GTYQ CKAN VFLS LRAA DCLA A
遺伝子ID:256933
Uniprot:Q8NG41
セルラーロケーション:Secreted
計算された分子量:13kDa
観察された分子量:13kDa
同義語:NPB, L7, PPL7, PPNPB
バックグラウンド:This gene encodes a member of the neuropeptide B/W family of proteins and preproprotein that is proteolytically processed to generate multiple protein products. The encoded products include neuropeptide B-23 and a C-terminally extended form, neuropeptide B-29, which are characterized by an N-terminal brominated tryptophan amino acid. Both of the encoded peptides bind with higher affinity to neuropeptide B/W (NPB/W) receptor 1 compared to the related NPB/W receptor 2. These peptides may regulate feeding, pain perception, and stress in rodents.
UniProt Protein Function:NPB: May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. Belongs to the neuropeptide B/W family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: extracellular region

Molecular Function:protein binding; G-protein-coupled receptor binding

Biological Process: G-protein coupled receptor protein signaling pathway; neuropeptide signaling pathway

NCBI Summary:This gene encodes a member of the neuropeptide B/W family of proteins and preproprotein that is proteolytically processed to generate multiple protein products. The encoded products include neuropeptide B-23 and a C-terminally extended form, neuropeptide B-29, which are characterized by an N-terminal brominated tryptophan amino acid. Both of the encoded peptides bind with higher affinity to neuropeptide B/W (NPB/W) receptor 1 compared to the related NPB/W receptor 2. These peptides may regulate feeding, pain perception, and stress in rodents. [provided by RefSeq, Jul 2015]
UniProt Code:Q8NG41
NCBI GenInfo Identifier:22507403
NCBI Gene ID:256933
NCBI Accession:NP_683694.1
UniProt Related Accession:Q8NG41
Molecular Weight:13kDa
NCBI Full Name:neuropeptide B preproprotein
NCBI Synonym Full Names:neuropeptide B
NCBI Official Symbol:NPB  
NCBI Official Synonym Symbols:L7; PPL7; PPNPB  
NCBI Protein Information:neuropeptide B
UniProt Protein Name:Neuropeptide B
UniProt Synonym Protein Names:Preproprotein L7
Protein Family:Neuropeptide
UniProt Gene Name:NPB  
UniProt Entry Name:NPB_HUMAN
Anti-NPB Antibody (CAB16612)Western blot analysis of extracts of various cell lines, using NPB antibody (CAB16612) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-NPB Antibody (CAB16612)Immunofluorescence analysis of HeLa cells using NPB Rabbit pAb (CAB16612) at dilution of 1:100. Blue: DAPI for nuclear staining.
Anti-NPB Antibody (CAB16612)Immunofluorescence analysis of NIH/3T3 cells using NPB Rabbit pAb (CAB16612) at dilution of 1:100. Blue: DAPI for nuclear staining.
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