Anti-NFATC3 Antibody (CAB6666)
- SKU:
- CAB6666
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-NFATC3 Antibody |
| 抗体コード: | CAB6666 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human NFATC3 (NP_775188.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Jurkat, Mouse thymus |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human NFATC3 (NP_775188.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MTTA NCGA HDEL DFKL VFGE DGAP APPP PGSR PADL EPDD CASI YIFN VDPP PSTL TTPL CLPH HGLP SHSS VLSP SFQL QSHK NYEG TCEI PESK YSPL GGPK PFEC PSIQ ITSI SPNC HQEL DAHE DDLQ INDP EREF LERP SRDH LYLP LEPS YRES SLSP SPAS SISS RSWF SDAS SCES LSHI YDDV DSEL NEAA ARFT LGSP LTSP GGSP GGCP GEET WHQQ YGLG HSLS PRQS PCHS PRSS VTDE NWLS PRPA SGPS SRPT SPCG KRRH SSAE VCYA GSLS PH |
| 遺伝子ID: | 4775 |
| Uniprot: | Q12968 |
| セルラーロケーション: | Cytoplasm, Nucleus |
| 計算された分子量: | 77kDa/80kDa/112kDa/115kDa |
| 観察された分子量: | 150kDa |
| 同義語: | NFATC3, NFAT4, NFATX |
| バックグラウンド: | The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. |
| UniProt Protein Function: | NFAT4: a transcription factor that plays a role in the inducible expression of cytokine genes in T cells. Plays a role in the regulation of gene expression in T cells and immature thymocytes. Six spliced isoforms have been identified. Isoform 1 is predominantly expressed in thymus, peripheral blood leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in thymus and kidney. Isoform 4 is expressed in thymus and skeletal muscle. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 16q22.2 Cellular Component: nucleoplasm; cytoplasm; nucleolus; cytosol; nucleus Molecular Function:protein binding; chromatin binding Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; patterning of blood vessels; heart development; cellular respiration; muscle cell development; innate immune response; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; inflammatory response |
| NCBI Summary: | The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010] |
| UniProt Code: | Q12968 |
| NCBI GenInfo Identifier: | 9087155 |
| NCBI Gene ID: | 4775 |
| NCBI Accession: | Q12968.1 |
| UniProt Secondary Accession: | Q12968,O75211, Q14516, Q99840, Q99841, Q99842, |
| UniProt Related Accession: | Q12968 |
| Molecular Weight: | 1075 |
| NCBI Full Name: | Nuclear factor of activated T-cells, cytoplasmic 3 |
| NCBI Synonym Full Names: | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 |
| NCBI Official Symbol: | NFATC3 |
| NCBI Official Synonym Symbols: | NFAT4; NFATX |
| NCBI Protein Information: | nuclear factor of activated T-cells, cytoplasmic 3; NF-ATc3; T cell transcription factor NFAT4; nuclear factor of activated T-cells c3 isoform IE-Xa |
| UniProt Protein Name: | Nuclear factor of activated T-cells, cytoplasmic 3 |
| UniProt Synonym Protein Names: | NFATx; T-cell transcription factor NFAT4; NF-AT4 |
| Protein Family: | Nuclear factor of activated T-cells |
| UniProt Gene Name: | NFATC3 |
| UniProt Entry Name: | NFAC3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NFATC3 antibody (CAB6666) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunohistochemistry of paraffin-embedded human colon carcinoma using NFATC3 Rabbit pAb (CAB6666) at dilution of 1:200 (40x lens). |
 | Immunofluorescence analysis of HeLa cells using NFATC3 antibody (CAB6666). Blue: DAPI for nuclear staining. |
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