Anti-NFASC Antibody (CAB3053)
- SKU:
- CAB3053
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-NFASC Antibody |
抗体コード: | CAB3053 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 830-1100 of human NFASC (NP_001005388.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | SH-SY5Y, HeLa, HL-60, Mouse brain, Mouse pancreas, Rat brain |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 830-1100 of human NFASC (NP_001005388.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | RFRV RQPN LETI NLEW DHPE HPNG IMIG YTLK YVAF NGTK VGKQ IVEN FSPN QTKF TVQR TDPV SRYR FTLS ARTQ VGSG EAVT EESP APPN EATP TAAP PTLP PTTV GATG AVSS TDAT AIAA TTEA TTVP IIPT VAPT TIAT TTTV ATTT TTTA AATT TTES PPTT TSGT KIHE SAPD EQSI WNVT VLPN SKWA NITW KHNF GPGT DFVV EYID SNHT KKTV PVKA QAQP IQLT DLYP GMTY TLRV YSRD NEGI SSTV ITFM TSTA YTN |
遺伝子ID: | 23114 |
Uniprot: | O94856 |
セルラーロケーション: | Cell membrane, Single-pass type I membrane protein |
計算された分子量: | 69kDa/119kDa/130-150kDa |
観察された分子量: | 150kDa |
同義語: | NFASC, NF, NRCAML |
バックグラウンド: | This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined. |
UniProt Protein Function: | neurofascin: Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions. Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. 13 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 1q32.1 Cellular Component: focal adhesion; paranode region of axon; integral to membrane; plasma membrane; intracellular Molecular Function:protein binding Biological Process: myelination; heterotypic cell-cell adhesion; axon guidance; clustering of voltage-gated sodium channels; synapse organization and biogenesis; transmission of nerve impulse; peripheral nervous system development; paranodal junction assembly |
NCBI Summary: | This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009] |
UniProt Code: | O94856 |
NCBI GenInfo Identifier: | 83304988 |
NCBI Gene ID: | 23114 |
NCBI Accession: | O94856.4 |
UniProt Secondary Accession: | O94856,Q149P5, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4 B2RNN8, B3KQZ1, B5MDP6, B5MDR6, B7ZMD8, |
UniProt Related Accession: | O94856 |
Molecular Weight: | 1240 |
NCBI Full Name: | Neurofascin |
NCBI Synonym Full Names: | neurofascin |
NCBI Official Symbol: | NFASC |
NCBI Official Synonym Symbols: | NF; NRCAML |
NCBI Protein Information: | neurofascin; neurofascin homolog |
UniProt Protein Name: | Neurofascin |
Protein Family: | Neurofascin |
UniProt Gene Name: | NFASC |
UniProt Entry Name: | NFASC_HUMAN |
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