Anti-Neogenin Antibody (CAB9413)
- SKU:
- CAB9413
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-Neogenin Antibody |
| 抗体コード: | CAB9413 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 160-340 of human NEO1 (NP_002490.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:1000 |
| 反応性: | Human |
| ポジティブサンプル: | MCF7 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 160-340 of human NEO1 (NP_002490.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | PSSV YAGN NAIL NCEV NADL VPFV RWEQ NRQP LLLD DRVI KLPS GMLV ISNA TEGD GGLY RCVV ESGG PPKY SDEV ELKV LPDP EVIS DLVF LKQP SPLV RVIG QDVV LPCV ASGL PTPT IKWM KNEE ALDT ESSE RLVL LAGG SLEI SDVT EDDA GTYF CIAD NGNE TIEA QAEL TVQA Q |
| 遺伝子ID: | 4756 |
| Uniprot: | Q92859 |
| セルラーロケーション: | Cell membrane, Single-pass type I membrane protein |
| 計算された分子量: | 154kDa/158kDa/160kDa |
| 観察された分子量: | 160kDa |
| 同義語: | NEO1, IGDCC2, NGN, NTN1R2, neogenin |
| バックグラウンド: | This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | NEO1: May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues. Belongs to the immunoglobulin superfamily. DCC family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 15q22.3-q23 Cellular Component: Golgi apparatus; nucleoplasm; plasma membrane Biological Process: iron ion homeostasis |
| NCBI Summary: | This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010] |
| UniProt Code: | Q92859 |
| NCBI GenInfo Identifier: | 116242676 |
| NCBI Gene ID: | 4756 |
| NCBI Accession: | Q92859.2 |
| UniProt Secondary Accession: | Q92859,O00340, Q17RX1, B7ZKM9, B7ZKN0, |
| UniProt Related Accession: | Q92859 |
| Molecular Weight: | 158,827 Da |
| NCBI Full Name: | Neogenin |
| NCBI Synonym Full Names: | neogenin 1 |
| NCBI Official Symbol: | NEO1 |
| NCBI Official Synonym Symbols: | NGN; IGDCC2; NTN1R2 |
| NCBI Protein Information: | neogenin |
| UniProt Protein Name: | Neogenin |
| UniProt Synonym Protein Names: | Immunoglobulin superfamily DCC subclass member 2 |
| Protein Family: | Neogenin |
| UniProt Gene Name: | NEO1 |
| UniProt Entry Name: | NEO1_HUMAN |
 | Western blot analysis of extracts of MCF-7 cells, using NEO1 antibody (CAB9413) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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