Anti-NECAB3 Antibody (CAB15500)
- SKU:
- CAB15500
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-NECAB3 Antibody |
| 抗体コード: | CAB15500 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-362 of human NECAB3 (NP_112508.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:200 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | LO2, Mouse liver, Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-362 of human NECAB3 (NP_112508.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MACA GLLT VCLL RPPA PQPQ PQTP RHPQ LAPD PGPA GHTL FQDV FRRA DKND DGKL SFEE FQNY FADG VLSL GELQ ELFS GIDG HLTD NLET EKLC DYFS EHLG VYRP VLAA LESL NRAV LAAM DATK LEYE RASK VDQF VTRF LLRE TVSQ LQAL QSSL EGAS DTLE AQAH GWRS DAES VEAQ SRLC GSRR AGRR ALRS VSRS STWS PGSS DTGR SSEA EMQW RLQV NRLQ ELID QLEC KAPR LEPL REED LAKG PDLH ILMA QRQV QVAE EGLQ DFHR ALRC YVDF TGAQ SHCL HVSA QKML DGAS FTLY EFWQ DEAS WRRH QQSP GSKA FQRI LIDH LRAP DTLT TVFF PASW WIMN NN |
| 遺伝子ID: | 63941 |
| Uniprot: | Q96P71 |
| セルラーロケーション: | Golgi apparatus |
| 計算された分子量: | 22kDa/40kDa/44kDa |
| 観察された分子量: | 50kDa |
| 同義語: | NECAB3, APBA2BP, EFCBP3, NIP1, STIP3, SYTIP2, XB51, dJ63M2.4, dJ63M2.5 |
| バックグラウンド: | The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | NECAB3: Inhibits the interaction of APBA2 with beta-amyloid precursor protein (APP), and hence allows formation of beta- amyloid. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 20q11.22 Cellular Component: endoplasmic reticulum membrane; cytoplasm; Golgi cis cisterna; nucleus Molecular Function:protein binding; calcium ion binding Biological Process: regulation of amyloid precursor protein biosynthetic process; protein metabolic process; protein secretion |
| NCBI Summary: | The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96P71 |
| NCBI GenInfo Identifier: | 149158725 |
| NCBI Gene ID: | 63941 |
| NCBI Accession: | NP_112508.3 |
| UniProt Secondary Accession: | Q96P71,Q5JWF5, Q5JWF6, Q5JWF7, Q86VV1, Q9H433, Q9H8G8 Q9HBW7, Q9HCQ9, A8K780, E1P5N2, |
| UniProt Related Accession: | Q96P71 |
| Molecular Weight: | 44,350 Da |
| NCBI Full Name: | N-terminal EF-hand calcium-binding protein 3 isoform 1 |
| NCBI Synonym Full Names: | N-terminal EF-hand calcium binding protein 3 |
| NCBI Official Symbol: | NECAB3 |
| NCBI Official Synonym Symbols: | NIP1; XB51; STIP3; EFCBP3; SYTIP2; APBA2BP; dJ63M2.4; dJ63M2.5 |
| NCBI Protein Information: | N-terminal EF-hand calcium-binding protein 3; X11L-binding protein 51; Nek2-interacting protein 1; EF-hand calcium binding protein 3; neuronal calcium-binding protein 3; synaptotagmin interacting protein 2; neuronal calcium-binding protein NECAB3; synapto |
| UniProt Protein Name: | N-terminal EF-hand calcium-binding protein 3 |
| UniProt Synonym Protein Names: | Amyloid beta A4 protein-binding family A member 2-binding protein; Nek2-interacting protein 1; Neuronal calcium-binding protein 3; X11L-binding protein 51 |
| Protein Family: | N-terminal EF-hand calcium-binding protein |
| UniProt Gene Name: | NECAB3 |
| UniProt Entry Name: | NECA3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NECAB3 antibody (CAB15500) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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