Anti-MYRF Antibody (CAB16355)
- SKU:
- CAB16355
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
| 抗体名: | Anti-MYRF Antibody |
| 抗体コード: | CAB16355 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MYRF (NP_001120864.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | HeLa, HepG2 |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MYRF (NP_001120864.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MEVV DETE ALQR FFEG HDIN GALE PSNI DTSI LEEY ISKE DASD LCFP DISA PASS ASYS HGQP AMPG SSGV HHLS PPGG GPSP GRHG PLPP PGYG TPLN |
| 遺伝子ID: | 745 |
| Uniprot: | Q9Y2G1 |
| セルラーロケーション: | Cytoplasm, Endoplasmic reticulum membrane, Nucleus, Single-pass membrane protein |
| 計算された分子量: | 120kDa/124kDa |
| 観察された分子量: | 124kDa |
| 同義語: | MYRF, C11orf9, MRF, Ndt80, pqn-47 |
| バックグラウンド: | This gene encodes a transcription factor that is required for central nervous system myelination and may regulate oligodendrocyte differentiation. It is thought to act by increasing the expression of genes that effect myelin production but may also directly promote myelin gene expression. Loss of a similar gene in mouse models results in severe demyelination. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | Myelin regulatory factor: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes (PubMed:23966832). |
| NCBI Summary: | This gene encodes a transcription factor that is required for central nervous system myelination and may regulate oligodendrocyte differentiation. It is thought to act by increasing the expression of genes that effect myelin production but may also directly promote myelin gene expression. Loss of a similar gene in mouse models results in severe demyelination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014] |
| UniProt Code: | Q9Y2G1 |
| NCBI GenInfo Identifier: | 188528652 |
| NCBI Gene ID: | 745 |
| NCBI Accession: | NP_001120864.1 |
| UniProt Secondary Accession: | Q9Y2G1,O43582, Q9P1Q6, |
| UniProt Related Accession: | Q9Y2G1 |
| Molecular Weight: | 120,225 Da |
| NCBI Full Name: | myelin regulatory factor isoform 2 |
| NCBI Synonym Full Names: | myelin regulatory factor |
| NCBI Official Symbol: | MYRF |
| NCBI Official Synonym Symbols: | MRF; Ndt80; pqn-47; C11orf9 |
| NCBI Protein Information: | myelin regulatory factor |
| UniProt Protein Name: | Myelin regulatory factor |
| UniProt Synonym Protein Names: | Myelin gene regulatory factor |
| UniProt Gene Name: | MYRF |
 | Western blot analysis of extracts of various cell lines, using MYRF Rabbit pAb (CAB16355) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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