| UniProt Protein Function: | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:9490638, PubMed:26529257). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). |
| NCBI Summary: | This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q13459 |
| NCBI GenInfo Identifier: | 33356170 |
| NCBI Gene ID: | 4650 |
| NCBI Accession: | NP_004136.2 |
| UniProt Secondary Accession: | Q13459,O75314, Q9NUJ2, Q9UHN0, |
| UniProt Related Accession: | Q13459 |
| Molecular Weight: | Observed: 250 kDPredicted: 244 kDa |
| NCBI Full Name: | unconventional myosin-IXb isoform 1 |
| NCBI Synonym Full Names: | myosin IXB |
| NCBI Official Symbol: | MYO9B |
| NCBI Official Synonym Symbols: | MYR5; CELIAC4 |
| NCBI Protein Information: | unconventional myosin-IXb |
| UniProt Protein Name: | Unconventional myosin-IXb |
| UniProt Synonym Protein Names: | Unconventional myosin-9b |
| Protein Family: | Unconventional myosin |
| UniProt Gene Name: | MYO9B |
