Anti-MYBPC3 Antibody (CAB12351)
- SKU:
- CAB12351
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-MYBPC3 Antibody |
| 抗体コード: | CAB12351 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-400 of human MYBPC3 (NP_000247.2). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Rat heart |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-400 of human MYBPC3 (NP_000247.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | SSKV GQHL QLHD SYDR ASKV YLFE LHIT DAQP AFTG SYRC EVST KDKF DCSN FNLT VHEA MGTG DLDL LSAF RRTS LAGG GRRI SDSH EDTG ILDF SSLL KKRD SFRT PRDS KLEA PAEE DVWE ILRQ APPS EYER IAFQ YGVT DLRG MLKR LKGM RRDE KKST AFQK KLEP AYQV SKGH KIRL TVEL ADHD AEVK WLKN G |
| 遺伝子ID: | 4607 |
| Uniprot: | Q14896 |
| セルラーロケーション: | |
| 計算された分子量: | 140kDa |
| 観察された分子量: | 170kDa |
| 同義語: | MYBPC3, CMD1MM, CMH4, FHC, LVNC10, MYBP-C, cardiac |
| バックグラウンド: | MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. |
| UniProt Protein Function: | MYBPC3: Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. Belongs to the immunoglobulin superfamily. MyBP family. |
| UniProt Protein Details: | Protein type:Myosin-binding Chromosomal Location of Human Ortholog: 11p11.2 Cellular Component: A band; cytosol; sarcomere; striated muscle thick filament Molecular Function:ATPase activator activity; identical protein binding; myosin binding; myosin heavy chain binding; protein binding; structural constituent of muscle Biological Process: cardiac muscle contraction; heart morphogenesis; muscle filament sliding; positive regulation of ATPase activity; regulation of muscle filament sliding; regulation of striated muscle contraction; ventricular cardiac muscle morphogenesis Disease: Cardiomyopathy, Familial Hypertrophic, 4; Left Ventricular Noncompaction 10 |
| NCBI Summary: | MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14896 |
| NCBI GenInfo Identifier: | 425906074 |
| NCBI Gene ID: | 4607 |
| NCBI Accession: | Q14896.4 |
| UniProt Secondary Accession: | Q14896,Q16410, Q6R2F7, Q9UE27, Q9UM53, A5PL00, |
| UniProt Related Accession: | Q14896 |
| Molecular Weight: | 140,703 Da |
| NCBI Full Name: | Myosin-binding protein C, cardiac-type |
| NCBI Synonym Full Names: | myosin binding protein C, cardiac |
| NCBI Official Symbol: | MYBPC3 |
| NCBI Official Synonym Symbols: | FHC; CMH4; CMD1MM; LVNC10; MYBP-C |
| NCBI Protein Information: | myosin-binding protein C, cardiac-type |
| UniProt Protein Name: | Myosin-binding protein C, cardiac-type |
| UniProt Synonym Protein Names: | C-protein, cardiac muscle isoform |
| Protein Family: | Myosin-binding protein |
| UniProt Gene Name: | MYBPC3 |
| UniProt Entry Name: | MYPC3_HUMAN |
 | Western blot analysis of extracts of rat heart, using MYBPC3 antibody (CAB12351) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
 | Immunohistochemistry of paraffin-embedded rat heart using MYBPC3 antibody (CAB12351) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse heart using MYBPC3 antibody (CAB12351) at dilution of 1:100 (40x lens). |
View AllClose