Anti-MTSS1 Antibody (CAB11697)
- SKU:
- CAB11697
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-MTSS1 Antibody |
| 抗体コード: | CAB11697 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 630-730 of human MTSS1 (NP_055566.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa, HT-29, U-87MG, Mouse liver, Mouse brain, Mouse heart, Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 630-730 of human MTSS1 (NP_055566.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LPAP PDGP EERG EHSP ESPS VGEG PQGV TSMP SSMW SGQA SVNP PLPG PKPS IPEE HRQA IPES EAED QERE PPSA TVSP GQIP ESDP ADLS PRDT PQGE D |
| 遺伝子ID: | 9788 |
| Uniprot: | O43312 |
| セルラーロケーション: | Cytoplasm, cytoskeleton |
| 計算された分子量: | 50kDa/79kDa/82kDa |
| 観察された分子量: | 115kDa |
| 同義語: | MTSS1, MIM, MIMA, MIMB |
| バックグラウンド: |
| UniProt Protein Function: | MTSS1: an intracellular protein that binds to actin and cortactin, and possesses tumor suppressor activity. Binds to the cytoplasmic domain of receptor protein tyrosine phosphatase delta. Senses and induces curved membranous curvatures important for cellular polarization, mobilization and endocytosis. May be related to cancer progression or tumor metastasis in a variety of organ sites. Its expression is down-regulated by MiR-135a. Downregulated in prostate cancer. Expressed in many tissues, including spleen, thymus, prostate, testis, uterus, colon, and peripheral blood. Belongs to the MTSS1 family. Three isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Motility/polarity/chemotaxis; Tumor suppressor Chromosomal Location of Human Ortholog: 8q24.13 Cellular Component: actin cytoskeleton; cytoplasm; endocytic vesicle Molecular Function:actin monomer binding; identical protein binding; protein binding; receptor binding Biological Process: actin cytoskeleton organization and biogenesis; negative regulation of epithelial cell proliferation; transmembrane receptor protein tyrosine kinase signaling pathway |
| UniProt Code: | O43312 |
| NCBI GenInfo Identifier: | 30923156 |
| NCBI Gene ID: | 9788 |
| NCBI Accession: | O43312.2 |
| UniProt Secondary Accession: | O43312,Q8TCA2, Q96RX2, J3KNK6, |
| UniProt Related Accession: | O43312 |
| Molecular Weight: | 82kDa |
| NCBI Full Name: | Metastasis suppressor protein 1 |
| NCBI Synonym Full Names: | MTSS1, I-BAR domain containing |
| NCBI Official Symbol: | MTSS1 |
| NCBI Official Synonym Symbols: | MIM; MIMA; MIMB |
| NCBI Protein Information: | metastasis suppressor protein 1 |
| UniProt Protein Name: | Metastasis suppressor protein 1 |
| UniProt Synonym Protein Names: | Metastasis suppressor YGL-1; Missing in metastasis protein |
| Protein Family: | MTSS1-like protein |
| UniProt Gene Name: | MTSS1 |
 | Western blot analysis of extracts of various cell lines, using MTSS1 antibody (CAB11697) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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