Anti-MRPL41 Antibody (CAB17760)
- SKU:
- CAB17760
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-MRPL41 Antibody |
| 抗体コード: | CAB17760 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-137 of human MRPL41 (NP_115866.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 293T, PC-3, MCF7 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-137 of human MRPL41 (NP_115866.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MGVL AAAA RCLV RGAD RMSK WTSK RGPR SFRG RKGR GAKG IGFL TSGW RFVQ IKEM VPEF VVPD LTGF KLKP YVSY LAPE SEET PLTA AQLF SEAV APAI EKDF KDGT FDPD NLEK YGFE PTQE GKLF QLYP RNFL R |
| 遺伝子ID: | 64975 |
| Uniprot: | Q8IXM3 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | 15kDa |
 | Western blot - MRPL41 Polyclonal Antibody (CAB17760) |
| 同義語: | BMRP, MRP-L27, MRPL27, PIG3, RPML27, MRPL41 |
| バックグラウンド: | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | MRPL41: Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins. Belongs to the ribosomal protein L41 family. |
| UniProt Protein Details: | Protein type:Mitochondrial; RNA-binding Chromosomal Location of Human Ortholog: 9q34.3 Cellular Component: mitochondrial inner membrane; mitochondrial large ribosomal subunit; mitochondrion; ribonucleoprotein complex Molecular Function:protein binding; structural constituent of ribosome Biological Process: apoptosis; cell cycle; mitochondrial translation; organelle organization and biogenesis; translation |
| NCBI Summary: | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8IXM3 |
| NCBI GenInfo Identifier: | 74750734 |
| NCBI Gene ID: | 64975 |
| NCBI Accession: | Q8IXM3.1 |
| UniProt Secondary Accession: | Q8IXM3,Q96Q49, |
| UniProt Related Accession: | Q8IXM3 |
| Molecular Weight: | 15,383 Da |
| NCBI Full Name: | 39S ribosomal protein L41, mitochondrial |
| NCBI Synonym Full Names: | mitochondrial ribosomal protein L41 |
| NCBI Official Symbol: | MRPL41 |
| NCBI Official Synonym Symbols: | BMRP; PIG3; MRPL27; RPML27; MRP-L27 |
| NCBI Protein Information: | 39S ribosomal protein L41, mitochondrial |
| UniProt Protein Name: | 39S ribosomal protein L41, mitochondrial |
| UniProt Synonym Protein Names: | 39S ribosomal protein L27 homolog; Bcl-2-interacting mitochondrial ribosomal protein L41; Cell proliferation-inducing gene 3 protein; MRP-L27 homolog |
| Protein Family: | 39S ribosomal protein |
| UniProt Gene Name: | MRPL41 |
| UniProt Entry Name: | RM41_HUMAN |