Anti-MPZL2 Antibody (CAB10549)
- SKU:
- CAB10549
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-MPZL2 Antibody |
| 抗体コード: | CAB10549 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-154 of human MPZL2 (NP_005788.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-154 of human MPZL2 (NP_005788.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VEIY TSRV LEAV NGTD ARLK CTFS SFAP VGDA LTVT WNFR PLDG GPEQ FVFY YHID PFQP MSGR FKDR VSWD GNPE RYDA SILL WKLQ FDDN GTYT CQVK NPPD VDGV IGEI RLSV VHTV RFSE IHFL |
| 遺伝子ID: | 10205 |
| Uniprot: | O60487 |
| セルラーロケーション: | Membrane, Single-pass type I membrane protein |
| 計算された分子量: | 24kDa |
| 観察された分子量: | Refer to Figures |
| 同義語: | MPZL2, EVA, EVA1 |
| バックグラウンド: | Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene. |
| UniProt Protein Function: | MPZL2: Mediates homophilic cell-cell adhesion. Belongs to the myelin P0 protein family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11q23.3 Cellular Component: cytoskeleton Molecular Function:protein binding Biological Process: anatomical structure morphogenesis; homophilic cell adhesion |
| NCBI Summary: | Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O60487 |
| NCBI GenInfo Identifier: | 20137696 |
| NCBI Gene ID: | 10205 |
| NCBI Accession: | O60487.1 |
| UniProt Secondary Accession: | O60487,A8K2R1, |
| UniProt Related Accession: | O60487 |
| Molecular Weight: | 24kDa |
| NCBI Full Name: | Myelin protein zero-like protein 2 |
| NCBI Synonym Full Names: | myelin protein zero like 2 |
| NCBI Official Symbol: | MPZL2 |
| NCBI Official Synonym Symbols: | EVA; EVA1 |
| NCBI Protein Information: | myelin protein zero-like protein 2 |
| UniProt Protein Name: | Myelin protein zero-like protein 2 |
| UniProt Synonym Protein Names: | Epithelial V-like antigen 1 |
| Protein Family: | Myelin protein zero-like protein |
| UniProt Gene Name: | MPZL2 |
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