| バックグラウンド: | This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity. |
| NCBI Summary: | This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] |
| UniProt Code: | Q00013 |
| NCBI GenInfo Identifier: | 1346575 |
| NCBI Gene ID: | 4354 |
| NCBI Accession: | Q00013.2 |
| UniProt Secondary Accession: | Q00013,Q2TSB6, Q5J7V5, B4DZV5, G3XAI1, |
| UniProt Related Accession: | Q00013 |
| Molecular Weight: | 49,854 Da |
| NCBI Full Name: | 55 kDa erythrocyte membrane protein |
| NCBI Synonym Full Names: | membrane palmitoylated protein 1 |
| NCBI Official Symbol: | MPP1 |
| NCBI Official Synonym Symbols: | MRG1; PEMP; AAG12; EMP55; DXS552E |
| NCBI Protein Information: | 55 kDa erythrocyte membrane protein |
| UniProt Protein Name: | 55 kDa erythrocyte membrane protein |
| UniProt Synonym Protein Names: | Membrane protein, palmitoylated 1 |
| Protein Family: | Mitochondrial-processing peptidase |
| UniProt Gene Name: | MPP1 |
| UniProt Entry Name: | EM55_HUMAN |
