Anti-MED19 Antibody (CAB20014)
- SKU:
- CAB20014
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
抗体名: | Anti-MED19 Antibody |
抗体コード: | CAB20014 |
抗体サイズ: | 100 uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | A synthetic peptide of human MED19 |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | Jurkat, Raji, NCI-H929 |
免疫原: | A synthetic peptide of human MED19 |
精製方法: | Affinity purification |
ストレージバッファ: | Store at 4?. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 219541 |
Uniprot: | A0JLT2 |
セルラーロケーション: | Nucleus |
計算された分子量: | 20kDa/26kDa |
観察された分子量: | 23kDa |
同義語: | DT2P1G7, LCMR1, MED19AS, MED19 |
バックグラウンド: | The protein encoded by this gene is a subunit of the Mediator complex, which binds to gene-specific regulatory factors and provides support for the basal RNA polymerase II transcription machinery. This gene has been implicated in the growth of several types of cancer, and inhibition of its expression inhibits the growth and spread of these cancers. Two transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | MED19: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Belongs to the Mediator complex subunit 19 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 11q12.1 Cellular Component: nucleus Molecular Function:protein binding |
NCBI Summary: | The protein encoded by this gene is a subunit of the Mediator complex, which binds to gene-specific regulatory factors and provides support for the basal RNA polymerase II transcription machinery. This gene has been implicated in the growth of several types of cancer, and inhibition of its expression inhibits the growth and spread of these cancers. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015] |
UniProt Code: | A0JLT2 |
NCBI GenInfo Identifier: | 158705879 |
NCBI Gene ID: | 219541 |
NCBI Accession: | A0JLT2.2 |
UniProt Secondary Accession: | A0JLT2,Q8IV02, Q8IZD1, |
UniProt Related Accession: | A0JLT2 |
Molecular Weight: | 20,431 Da |
NCBI Full Name: | Mediator of RNA polymerase II transcription subunit 19 |
NCBI Synonym Full Names: | mediator complex subunit 19 |
NCBI Official Symbol: | MED19 |
NCBI Official Synonym Symbols: | LCMR1; DT2P1G7; MED19AS |
NCBI Protein Information: | mediator of RNA polymerase II transcription subunit 19 |
UniProt Protein Name: | Mediator of RNA polymerase II transcription subunit 19 |
UniProt Synonym Protein Names: | Lung cancer metastasis-related protein 1; Mediator complex subunit 19 |
Protein Family: | Putative mediator of RNA polymerase II transcription |
UniProt Gene Name: | MED19 |
UniProt Entry Name: | MED19_HUMAN |