Anti-MCAM Antibody (CAB1962)
- SKU:
- CAB1962
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-MCAM Antibody |
| 抗体コード: | CAB1962 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 447-646 of human MCAM (NP_006491.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | HeLa |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 447-646 of human MCAM (NP_006491.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VLNL SCEA SGHP RPTI SWNV NGTA SEQD QDPQ RVLS TLNV LVTP ELLE TGVE CTAS NDLG KNTS ILFL ELVN LTTL TPDS NTTT GLST STAS PHTR ANST STER KLPE PESR GVVI VAVI VCIL VLAV LGAV LYFL YKKG KLPC RRSG KQEI TLPP SRKS ELVV EVKS DKLP EEMG LLQG SSGD KRAP GDQG EKYI DLRH |
| 遺伝子ID: | 4162 |
| Uniprot: | P43121 |
| セルラーロケーション: | Membrane, Single-pass type I membrane protein |
| 計算された分子量: | 57kDa/71kDa |
| 観察された分子量: | 120kDa |
| 同義語: | MCAM, CD146, MUC18 |
| バックグラウンド: |
| UniProt Protein Function: | MCAM: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, integral Chromosomal Location of Human Ortholog: 11q23.3 Cellular Component: extracellular space; focal adhesion; integral to membrane; plasma membrane; nucleus; external side of plasma membrane Biological Process: anatomical structure morphogenesis; glomerular filtration; angiogenesis; cell adhesion; positive regulation of cell migration |
| UniProt Code: | P43121 |
| NCBI GenInfo Identifier: | 85681878 |
| NCBI Gene ID: | 4162 |
| NCBI Accession: | P43121.2 |
| UniProt Secondary Accession: | P43121,O95812, Q59E86, Q6PHR3, Q6ZTR2, |
| UniProt Related Accession: | P43121 |
| Molecular Weight: | 646 |
| NCBI Full Name: | Cell surface glycoprotein MUC18 |
| NCBI Synonym Full Names: | melanoma cell adhesion molecule |
| NCBI Official Symbol: | MCAM |
| NCBI Official Synonym Symbols: | CD146; MUC18 |
| NCBI Protein Information: | cell surface glycoprotein MUC18; Gicerin; melanoma adhesion molecule; cell surface glycoprotein P1H12; melanoma-associated antigen A32; melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen |
| UniProt Protein Name: | Cell surface glycoprotein MUC18 |
| UniProt Synonym Protein Names: | Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen; CD_antigen: CD146 |
| Protein Family: | Cell surface glycoprotein |
| UniProt Gene Name: | MCAM |
| UniProt Entry Name: | MUC18_HUMAN |
 | Western blot analysis of extracts of HeLa cells, using MCAM antibody (CAB1962) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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