| バックグラウンド: | The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. |
| NCBI Summary: | The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P42679 |
| NCBI GenInfo Identifier: | |
| NCBI Gene ID: | 4145 |
| NCBI Accession: | |
| UniProt Related Accession: | P42679 |
| Molecular Weight: | Observed MW: 56kDa |
| NCBI Full Name: | |
| NCBI Synonym Full Names: | megakaryocyte-associated tyrosine kinase |
| NCBI Official Symbol: | MATK |
| NCBI Official Synonym Symbols: | CHK; CTK; HYL; Lsk; HYLTK; HHYLTK |
| NCBI Protein Information: | megakaryocyte-associated tyrosine-protein kinase |
| UniProt Protein Name: | |
| Protein Family: | Maturase |
| UniProt Gene Name: | |
