Anti-MAP4K5 Antibody (CAB7962)
- SKU:
- CAB7962
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | MAP4K5 Rabbit Polyclonal Antibody |
| 抗体コード: | CAB7962 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-480 of human MAP4K5 (NP_006566.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | MCF7, A-549, Jurkat, Mouse brain, Mouse spleen, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-480 of human MAP4K5 (NP_006566.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | HAHY TEAD DDDF EPHA IIRH TIRS TNRN ARAE RTAS EINF DKLQ FEPP LRKE TEAR DEMG LSSD PNFM LQWN PFVD GANT GKST SKRA IPPP LPPK PRIS SYPE DNFP DEEK ASTI KHCP DSES RAPQ ILRR QSSP SCGP VAET SSIG NGDG ISKL MSEN TEGS AQAP QLPR KKDK RDFP K |
| 遺伝子ID: | 11183 |
| Uniprot: | Q9Y4K4 |
| セルラーロケーション: | Cytoplasm |
| 計算された分子量: | 95kDa |
| 観察された分子量: | 120kDa |
| 同義語: | MAP4K5, GCKR, KHS, KHS1, MAPKKKK5 |
| バックグラウンド: | This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. |
| UniProt Protein Function: | KHS1: a serine/threonine protein kinase of the STE20 family. Highly similar to yeast SPS1/STE20 kinase. Activates Jun kinase in mammalian cells, which suggested a role in stress response. |
| UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, STE; EC 2.7.11.1; STE group; STE20 family; KHS subfamily Chromosomal Location of Human Ortholog: 14q11.2-q21 Cellular Component: cytoplasm; plasma membrane Molecular Function:protein serine/threonine kinase activity; protein binding; ATP binding; protein kinase activity; receptor signaling protein serine/threonine kinase activity Biological Process: protein amino acid phosphorylation; activation of JNK activity |
| NCBI Summary: | This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y4K4 |
| NCBI GenInfo Identifier: | 38570135 |
| NCBI Gene ID: | 11183 |
| NCBI Accession: | NP_942089 |
| UniProt Secondary Accession: | Q9Y4K4,Q8IYF6, |
| UniProt Related Accession: | Q9Y4K4 |
| Molecular Weight: | 95,040 Da |
| NCBI Full Name: | mitogen-activated protein kinase kinase kinase kinase 5 |
| NCBI Synonym Full Names: | mitogen-activated protein kinase kinase kinase kinase 5 |
| NCBI Official Symbol: | MAP4K5 |
| NCBI Official Synonym Symbols: | KHS; GCKR; KHS1; MAPKKKK5 |
| NCBI Protein Information: | mitogen-activated protein kinase kinase kinase kinase 5 |
| UniProt Protein Name: | Mitogen-activated protein kinase kinase kinase kinase 5 |
| UniProt Synonym Protein Names: | Kinase homologous to SPS1/STE20; KHS; MAPK/ERK kinase kinase kinase 5; MEK kinase kinase 5; MEKKK 5 |
| Protein Family: | Kievitone hydratase |
| UniProt Gene Name: | MAP4K5 |
| UniProt Entry Name: | M4K5_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MAP4K5 antibody (CAB7962) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s. |
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