Anti-MAP4K3 Antibody (CAB13375)
- SKU:
- CAB13375
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-MAP4K3 Antibody |
| 抗体コード: | CAB13375 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | IF |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 755-894 of human MAP4K3 (NP_003609.2). |
| 申し込み: | IF |
| 推奨希釈: | IF 1:50 - 1:200 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 755-894 of human MAP4K3 (NP_003609.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | ETVN PNST SSWF TESD TPQT NVTH VTQL ERDT ILVC LDCC IKIV NLQG RLKS SRKL SSEL TFDF QIES IVCL QDSV LAFW KHGM QGRS FRSN EVTQ EISD STRI FRLL GSDR VVVL ESRP TDNP TANS NLYI LAGH ENSY |
| 遺伝子ID: | 8491 |
| Uniprot: | Q8IVH8 |
| セルラーロケーション: | |
| 計算された分子量: | 98kDa/100kDa/101kDa |
| 観察された分子量: |
| 同義語: | MAP4K3, GLK, MAPKKKK3, MEKKK 3, MEKKK3, RAB8IPL1 |
| バックグラウンド: | This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. |
| UniProt Protein Function: | KHS2: an ubiquitous protein kinase of the STE20 family. May play a role in the response to environmental stress. Regulated by amino acids and acts upstream of mTORC1 and JNK. Required for maximal S6K and 4E-BP1 phosphorylation. Interacts with PPP2R5E, a regulatory subunit of PP2A. Following amino acid withdrawal, pS170 is dephosphorylated via PP2A. The dephosphorylation of pS170 by PP2A in response to amino acid restriction inhibits mTORC1 signaling. The inhibition of PPP2R5E expression prevents the dephosphorylation of KHS2 pS170, impairing mTORC1 inhibition during amino acid withdrawal. Three alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; STE group; STE20 family; KHS subfamily Chromosomal Location of Human Ortholog: 2p22.1 Cellular Component: cytoplasm Molecular Function:protein serine/threonine kinase activity; protein binding; ATP binding; protein kinase activity; receptor signaling protein serine/threonine kinase activity Biological Process: regulation of catalytic activity; JNK cascade; protein amino acid phosphorylation; response to UV |
| NCBI Summary: | This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012] |
| UniProt Code: | Q8IVH8 |
| NCBI GenInfo Identifier: | 29427817 |
| NCBI Gene ID: | 8491 |
| NCBI Accession: | Q8IVH8.1 |
| UniProt Secondary Accession: | Q8IVH8,Q6IQ39, Q8IVH7, Q9UDM5, Q9Y6R5, |
| UniProt Related Accession: | Q8IVH8 |
| Molecular Weight: | Observed MW: 110kDaCalculated MW: 98kDa/100kDa/101kDa |
| NCBI Full Name: | Mitogen-activated protein kinase kinase kinase kinase 3 |
| NCBI Synonym Full Names: | mitogen-activated protein kinase kinase kinase kinase 3 |
| NCBI Official Symbol: | MAP4K3 |
| NCBI Official Synonym Symbols: | GLK; MEKKK3; MEKKK 3; MAPKKKK3; RAB8IPL1 |
| NCBI Protein Information: | mitogen-activated protein kinase kinase kinase kinase 3; MEK kinase kinase 3; MAPK/ERK kinase kinase kinase 3; germinal center kinase-like kinase; germinal center kinase-related protein kinase |
| UniProt Protein Name: | Mitogen-activated protein kinase kinase kinase kinase 3 |
| UniProt Synonym Protein Names: | Germinal center kinase-related protein kinase; GLK; MAPK/ERK kinase kinase kinase 3; MEK kinase kinase 3; MEKKK 3 |
| Protein Family: | Mitogen-activated protein kinase kinase kinase kinase |
| UniProt Gene Name: | MAP4K3 |
| UniProt Entry Name: | M4K3_HUMAN |
 | Immunofluorescence analysis of A549 cells using MAP4K3 antibody (CAB13375). Blue: DAPI for nuclear staining. |
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