Anti-MAP3K3 Antibody (RACO0141)
- SKU:
- RACO0141
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- ELISA
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| 商品名: | MAP3K3 Antibody |
| Product SKU: | RACO0141 |
| サイズ: | 50ul |
| 宿主種: | Human |
| 申し込み: | ELISA |
| 推奨される希釈: | |
| 反応性: | Human |
| 免疫原: | A synthesized peptide derived from human MAP3K3 |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | Affinity-chromatography |
| 抗体のクローン性: | Monoclonal |
| アイソタイプ: | Rabbit IgG |
| Conjugate: | Non-conjugated |
| バックグラウンド: | Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. |
| シノニム: | Mitogen-activated protein kinase kinase kinase 3, MAPK/ERK kinase kinase 3, MEK kinase 3, MEKK 3, MAP3K3, MAPKKK3, MEKK3 |
| UniProt Protein Function: | MEKK3: a protein kinase of the STE11 family. Phosphorylated and activated by MLK3 and TAK1. Phosphorylates and activates MEK5. |
| UniProt Protein Details: | Protein type:Protein kinase, STE; Kinase, protein; EC 2.7.11.25; Protein kinase, Ser/Thr (non-receptor); STE group; STE11 family Chromosomal Location of Human Ortholog: 17q23.3 Cellular Component: intracellular; cytosol Molecular Function:MAP kinase kinase activity; protein binding; MAP kinase kinase kinase activity; metal ion binding; ATP binding; protein kinase activity Biological Process: blood vessel development; positive regulation of I-kappaB kinase/NF-kappaB cascade; activation of MAPKK activity; activation of MAPK activity; protein amino acid autophosphorylation; MAPKKK cascade |
| NCBI Summary: | This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q99759 |
| NCBI GenInfo Identifier: | 160332306 |
| NCBI Gene ID: | 4215 |
| NCBI Accession: | Q99759.2 |
| UniProt Secondary Accession: | Q99759,Q5BKZ6, Q8N3I9, B2RCW2, D3DU15, |
| UniProt Related Accession: | Q99759 |
| Molecular Weight: | 74,089 Da |
| NCBI Full Name: | Mitogen-activated protein kinase kinase kinase 3 |
| NCBI Synonym Full Names: | mitogen-activated protein kinase kinase kinase 3 |
| NCBI Official Symbol: | MAP3K3 |
| NCBI Official Synonym Symbols: | MEKK3; MAPKKK3 |
| NCBI Protein Information: | mitogen-activated protein kinase kinase kinase 3; MEKK 3; MEK kinase 3; MAP/ERK kinase kinase 3; MAPK/ERK kinase kinase 3 |
| UniProt Protein Name: | Mitogen-activated protein kinase kinase kinase 3 |
| UniProt Synonym Protein Names: | MAPK/ERK kinase kinase 3; MEK kinase 3; MEKK 3 |
| UniProt Gene Name: | MAP3K3 |
| UniProt Entry Name: | M3K3_HUMAN |