Anti-MAP3K13 Antibody (CAB10189)
- SKU:
- CAB10189
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-MAP3K13 Antibody |
| 抗体コード: | CAB10189 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 500-759 of human MAP3K13 (NP_001229246.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:3000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | BxPC-3, U-87MG, LO2, BT-474, Mouse kidney, Mouse pancreas |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 500-759 of human MAP3K13 (NP_001229246.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | CWRS SEPD KGQA GPWG CCQA DAYD PCLQ CRPE QYGS LDIP SAEP VGRS PDLS KSPA HNPL LENA QSSE KTEE NEFS GCRS ESSL GTSH LGTP PALP RKTR PLQK SGDD SSEE EEGE VDSE VEFP RRQR PHRC ISSC QSYS TFSS ENFS VSDG EEGN TSDH SNSP DELA DKLE DRLA EKLD DLLS QTPE IPID ISSH SDGL SDKE CAVR RVKT QMSL GKLC VEER GYEN PMQF EESD CDSS DGEC SDAT VRTN KHYS SATW |
| 遺伝子ID: | 9175 |
| Uniprot: | O43283 |
| セルラーロケーション: | Cytoplasm, Membrane, Peripheral membrane protein |
| 計算された分子量: | 14kDa/17kDa/85kDa/92kDa/108kDa |
| 観察された分子量: | 108kDa |
| 同義語: | MAP3K13, LZK, MEKK13, MLK |
| バックグラウンド: | The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. |
| UniProt Protein Function: | LZK: a TKL kinase of the MLK family. Synergizes with antioxidant protein-1 to activate NF-kappaB. Forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway. This kinase can phosphorylate and activate JNK and MKK7. Contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. |
| UniProt Protein Details: | Protein type:EC 2.7.11.25; Kinase, protein; LZK subfamily; MLK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group Chromosomal Location of Human Ortholog: 3q27.2 Cellular Component: IkappaB kinase complex; membrane Molecular Function:identical protein binding; MAP kinase kinase kinase activity; protein binding; protein homodimerization activity; protein kinase binding; protein serine/threonine kinase activity Biological Process: activation of MAPKK activity; activation of NF-kappaB transcription factor; JNK cascade; protein amino acid autophosphorylation; protein amino acid phosphorylation |
| NCBI Summary: | The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43283 |
| NCBI GenInfo Identifier: | 68052263 |
| NCBI Gene ID: | 9175 |
| NCBI Accession: | O43283.1 |
| UniProt Secondary Accession: | O43283,Q05BY6, Q15450, Q2NKN3, B2R6U2, B4DLE3, B4DMV2 B4DZJ4, D3DNU1, |
| UniProt Related Accession: | O43283 |
| Molecular Weight: | 108kDa |
| NCBI Full Name: | Mitogen-activated protein kinase kinase kinase 13 |
| NCBI Synonym Full Names: | mitogen-activated protein kinase kinase kinase 13 |
| NCBI Official Symbol: | MAP3K13 |
| NCBI Official Synonym Symbols: | LZK; MLK; MEKK13 |
| NCBI Protein Information: | mitogen-activated protein kinase kinase kinase 13 |
| UniProt Protein Name: | Mitogen-activated protein kinase kinase kinase 13 |
| UniProt Synonym Protein Names: | Leucine zipper-bearing kinase; Mixed lineage kinase; MLK |
| Protein Family: | Mitogen-activated protein kinase kinase kinase |
| UniProt Gene Name: | MAP3K13 |
 | Western blot analysis of extracts of various cell lines, using MAP3K13 antibody (CAB10189) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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