Anti-LNPEP Antibody (CAB11959)
- SKU:
- CAB11959
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-LNPEP Antibody |
| 抗体コード: | CAB11959 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human LNPEP (NP_005566.2). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 293T, HT-29, U-87MG, HeLa, Jurkat, Mouse brain, Mouse heart, Mouse liver, Rat heart |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human LNPEP (NP_005566.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MEPF TNDR LQLP RNMI ENSM FEEE PDVV DLAK EPCL HPLE PDEV EYEP RGSR LLVR GLGE HEME EDEE DYES SAKL LGMS FMNR SSGL RNSA TGYR QSPD GACS VPSA RT |
| 遺伝子ID: | 4012 |
| Uniprot: | Q9UIQ6 |
| セルラーロケーション: | Cell membrane, Secreted, Single-pass type II membrane protein |
| 計算された分子量: | 115kDa/117kDa |
| 観察された分子量: | 160kDa |
| 同義語: | LNPEP, CAP, IRAP, P-LAP, PLAP |
| バックグラウンド: | This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | IRAP: a leucyl/cystinyl aminopeptidase. A type II membrane protein and secreted. Resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. Three alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:EC 3.4.11.3; Membrane protein, integral; Protease Chromosomal Location of Human Ortholog: 5q15 Cellular Component: cytoplasmic vesicle membrane; cytosol; integral to plasma membrane; intracellular; lysosomal membrane; membrane; plasma membrane Molecular Function:aminopeptidase activity; metallopeptidase activity; peptide binding; protein binding; zinc ion binding Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; cell-cell signaling; female pregnancy; peptide catabolic process; protein polyubiquitination; regulation of blood pressure; signal transduction |
| NCBI Summary: | This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UIQ6 |
| NCBI GenInfo Identifier: | 145559489 |
| NCBI Gene ID: | 4012 |
| NCBI Accession: | Q9UIQ6.3 |
| UniProt Secondary Accession: | Q9UIQ6,O00769, Q15145, Q59H76, Q9TNQ2, Q9TNQ3, Q9UIQ7 |
| UniProt Related Accession: | Q9UIQ6 |
| Molecular Weight: | 117kDa |
| NCBI Full Name: | Leucyl-cystinyl aminopeptidase |
| NCBI Synonym Full Names: | leucyl and cystinyl aminopeptidase |
| NCBI Official Symbol: | LNPEP |
| NCBI Official Synonym Symbols: | CAP; IRAP; PLAP; P-LAP |
| NCBI Protein Information: | leucyl-cystinyl aminopeptidase |
| UniProt Protein Name: | Leucyl-cystinyl aminopeptidase |
| UniProt Synonym Protein Names: | Insulin-regulated membrane aminopeptidase; Insulin-responsive aminopeptidase; IRAP |
| Protein Family: | Leucyl-cystinyl aminopeptidase |
| UniProt Gene Name: | LNPEP |
 | Western blot analysis of extracts of various cell lines, using LNPEP antibody (CAB11959) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded rat liver using LNPEP Rabbit pAb (CAB11959) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat brain using LNPEP Rabbit pAb (CAB11959) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human placenta using LNPEP Rabbit pAb (CAB11959) at dilution of 1:100 (40x lens). |
View AllClose