Anti-Leptin Receptor Antibody (CAB2999)
- SKU:
- CAB2999
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-Leptin Receptor Antibody |
| 抗体コード: | CAB2999 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide of human LEPR |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:1000 |
| 反応性: | Human |
| ポジティブサンプル: | HeLa, K-562 |
| 免疫原: | A synthetic peptide of human LEPR |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 3953 |
| Uniprot: | P48357 |
| セルラーロケーション: | Cell membrane, Secreted, Single-pass type I membrane protein |
| 計算された分子量: | 96kDa/102kDa/103kDa/109kDa/132kDa |
| 観察された分子量: | 113kDa |
| 同義語: | CD295, LEP-R, LEPRD, OB-R, OBR, LEPR |
| バックグラウンド: | The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021). |
| UniProt Protein Function: | LEPR: the receptor for leptin (obesity factor). A single-transmembrane-domain receptor of the cytokine receptor family. On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Five alternatively spliced transcript variants have been reported. |
| UniProt Protein Details: | Protein type:Receptor, cytokine; Membrane protein, integral Chromosomal Location of Human Ortholog: 1p31 Cellular Component: plasma membrane; extracellular region; integral to membrane; receptor complex Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor activity; identical protein binding; protein binding; transmembrane receptor activity Biological Process: cholesterol metabolic process; cell surface receptor linked signal transduction; negative regulation of gluconeogenesis; multicellular organismal development; cytokine and chemokine mediated signaling pathway; negative regulation of hydrolase activity; energy reserve metabolic process Disease: Leptin Receptor Deficiency |
| NCBI Summary: | The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010] |
| UniProt Code: | P48357 |
| NCBI GenInfo Identifier: | 116242617 |
| NCBI Gene ID: | 3953 |
| NCBI Accession: | P48357.2 |
| UniProt Secondary Accession: | P48357,Q13592, Q13593, Q13594, Q92919, Q92920, Q92921 |
| UniProt Related Accession: | P48357 |
| Molecular Weight: | 96,042 Da |
| NCBI Full Name: | Leptin receptor |
| NCBI Synonym Full Names: | leptin receptor |
| NCBI Official Symbol: | LEPR |
| NCBI Official Synonym Symbols: | OBR; OB-R; CD295; LEP-R; LEPRD |
| NCBI Protein Information: | leptin receptor; huB219; OB receptor |
| UniProt Protein Name: | Leptin receptor |
| UniProt Synonym Protein Names: | HuB219; OB receptor; OB-R; CD_antigen: CD295 |
| Protein Family: | Leptin receptor |
| UniProt Gene Name: | LEPR |
| UniProt Entry Name: | LEPR_HUMAN |
 | Western blot analysis of extracts of various cell lines, using Leptin Receptor antibody (CAB2999) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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