Anti-KLK6 Antibody (CAB11972)
- SKU:
- CAB11972
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-KLK6 Antibody |
| 抗体コード: | CAB11972 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human KLK6 (NP_002765.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | U-87MG, Mouse brain, Rat testis, Rat brain |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human KLK6 (NP_002765.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | AASH DQDI MLLR LARP AKLS ELIQ PLPL ERDC SANT TSCH ILGW GKTA DGDF PDTI QCAY IHLV SREE CEHA YPGQ ITQN MLCA GDEK YGKD SCQG DSGG PLVC GDHL RGLV SWGN IPCG SKEK PGVY TNVC RYTN WIQK TIQA K |
| 遺伝子ID: | 5653 |
| Uniprot: | Q92876 |
| セルラーロケーション: | Cytoplasm, Microsome, Mitochondrion, Nucleus, Secreted, nucleolus |
| 計算された分子量: | 4kDa/15kDa/26kDa |
| 観察された分子量: | 27kDa |
| 同義語: | KLK6, Bssp, Klk7, PRSS18, PRSS9, SP59, hK6 |
| バックグラウンド: | This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The encoded preproprotein is proteolytically processed to generate the mature protease. Expression of this protease is regulated by steroid hormones and may be elevated in multiple human cancers and in serum from psoriasis patients. The encoded protease may participate in the cleavage of amyloid precursor protein and alpha-synuclein, thus implicating this protease in Alzheimer's and Parkinson's disease, respectively. This gene is located in a gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. |
| UniProt Protein Function: | KLK6: Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis. Belongs to the peptidase S1 family. Kallikrein subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protease; Secreted; EC 3.4.21.-; Secreted, signal peptide; Nucleolus Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: microtubule cytoskeleton; nucleoplasm; extracellular space; intercellular bridge; nuclear membrane; mitochondrion; endoplasmic reticulum; cytoplasm; extracellular region; nucleolus Molecular Function:protein binding; serine-type endopeptidase activity Biological Process: myelination; collagen catabolic process; protein autoprocessing; central nervous system development; tissue regeneration; amyloid precursor protein metabolic process; positive regulation of G-protein coupled receptor protein signaling pathway; regulation of cell differentiation; response to wounding; hormone metabolic process; protein processing; proteolysis |
| NCBI Summary: | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q92876 |
| NCBI GenInfo Identifier: | 3914480 |
| NCBI Gene ID: | 5653 |
| NCBI Accession: | Q92876.1 |
| UniProt Secondary Accession: | Q92876,Q6H301, A6NJA1, A8MW09, |
| UniProt Related Accession: | Q92876 |
| Molecular Weight: | 4,333 Da |
| NCBI Full Name: | Kallikrein-6 |
| NCBI Synonym Full Names: | kallikrein-related peptidase 6 |
| NCBI Official Symbol: | KLK6 |
| NCBI Official Synonym Symbols: | hK6; Bssp; Klk7; SP59; PRSS9; PRSS18 |
| NCBI Protein Information: | kallikrein-6; zyme; neurosin; protease M; serine protease 9; serine protease 18 |
| UniProt Protein Name: | Kallikrein-6 |
| UniProt Synonym Protein Names: | Neurosin; Protease M; SP59; Serine protease 18; Serine protease 9; Zyme |
| Protein Family: | Kallikrein |
| UniProt Gene Name: | KLK6 |
| UniProt Entry Name: | KLK6_HUMAN |
 | Western blot analysis of extracts of various cell lines, using KLK6 antibody (CAB11972) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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