Anti-KLK5 Antibody (CAB14863)
- SKU:
- CAB14863
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-KLK5 Antibody |
| 抗体コード: | CAB14863 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human KLK5 (NP_001070959.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | A-431 |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human KLK5 (NP_001070959.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | FPKV LQCL NISV LSQK RCED AYPR QIDD TMFC AGDK AGRD SCQG DSGG PVVC NGSL QGLV SWGD YPCA RPNR PGVY TNLC KFTK WIQE TIQA NS |
| 遺伝子ID: | 25818 |
| Uniprot: | Q9Y337 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 32kDa |
| 観察された分子量: | 37kDa |
| 同義語: | KLK5, KLK-L2, KLKL2, SCTE |
| バックグラウンド: | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. |
| UniProt Protein Function: | KLK5: May be involved in desquamation. Belongs to the peptidase S1 family. Kallikrein subfamily. |
| UniProt Protein Details: | Protein type:EC 3.4.21.-; Protease; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 19q13.33 Cellular Component: extracellular space Molecular Function:peptidase activity; protein binding; serine-type peptidase activity; serine-type endopeptidase activity Biological Process: epidermis development; positive regulation of G-protein coupled receptor protein signaling pathway; proteolysis |
| NCBI Summary: | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y337 |
| NCBI GenInfo Identifier: | 296434569 |
| NCBI Gene ID: | 25818 |
| NCBI Accession: | Q9Y337.2 |
| UniProt Secondary Accession: | Q9Y337,Q53ZR3, Q9HBG8, |
| UniProt Related Accession: | Q9Y337 |
| Molecular Weight: | 293 |
| NCBI Full Name: | Kallikrein-5 |
| NCBI Synonym Full Names: | kallikrein-related peptidase 5 |
| NCBI Official Symbol: | KLK5 |
| NCBI Official Synonym Symbols: | SCTE; KLKL2; KLK-L2 |
| NCBI Protein Information: | kallikrein-5; kallikrein 5; kallikrein-like protein 2; stratum corneum tryptic enzyme |
| UniProt Protein Name: | Kallikrein-5 |
| UniProt Synonym Protein Names: | Kallikrein-like protein 2; KLK-L2; Stratum corneum tryptic enzyme |
| Protein Family: | Kallikrein |
| UniProt Gene Name: | KLK5 |
| UniProt Entry Name: | KLK5_HUMAN |
 | Western blot analysis of extracts of A-431 cells, using KLK5 antibody (CAB14863) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
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