Anti-KIR3DS1 Antibody (CAB9936)
- SKU:
- CAB9936
- Product type:
- Antibody
- Application:
- WB
- Application:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-KIR3DS1 Antibody |
| 抗体コード: | CAB9936 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 80-340 of human KIR3DS1 (NP_001077008.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Jurkat, A-549, THP-1, BT-474, B cells, Mouse liver, Mouse kidney, Mouse pancreas, Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 80-340 of human KIR3DS1 (NP_001077008.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | FNMS PVTT AHAG NYTC RGSH PHSP TGWS APSN PMVI MVTG NHRK PSLL AHPG PLVK SGER VILQ CWSD IMFE HFFL HKEW ISKD PSRL VGQI HDGV SKAN FSIG SMMR ALAG TYRC YGSV THTP YQLS APSD PLDI VVTG LYEK PSLS AQPG PKVQ AGES VTLS CSSR SSYD MYHL SREG GAHE RRLP AVRK VNRT FQAD FPLG PATH GGTY RCFG SFRH SPYE WSDP SDPL LVSV TGNP SSSW PSPT EPSS KSGN LRHL H |
| 遺伝子ID: | 3813 |
| Uniprot: | Q14943 |
| セルラーロケーション: | Cell membrane, Single-pass type I membrane protein |
| 計算された分子量: | 42kDa |
| 観察された分子量: | 60kDa |
| 同義語: | KIR3DS1, CD158E2, KIR-123FM, KIR-G1, NKAT-10, NKAT10 |
| バックグラウンド: | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | KIR3DS1: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells. Belongs to the immunoglobulin superfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.4 Cellular Component: plasma membrane Biological Process: innate immune response |
| NCBI Summary: | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013] |
| UniProt Code: | Q14943 |
| NCBI GenInfo Identifier: | 2833258 |
| NCBI Gene ID: | 3813 |
| NCBI Accession: | Q14943.1 |
| UniProt Related Accession: | Q14943 |
| Molecular Weight: | 42,902 Da |
| NCBI Full Name: | Killer cell immunoglobulin-like receptor 3DS1 |
| NCBI Synonym Full Names: | killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1 |
| NCBI Official Symbol: | KIR3DS1 |
| NCBI Official Synonym Symbols: | KIR-G1; NKAT10; CD158E2; NKAT-10; KIR-123FM |
| NCBI Protein Information: | killer cell immunoglobulin-like receptor 3DS1 |
| UniProt Protein Name: | Killer cell immunoglobulin-like receptor 3DS1 |
| UniProt Synonym Protein Names: | MHC class I NK cell receptor; Natural killer-associated transcript 10; NKAT-10 |
| Protein Family: | Killer cell immunoglobulin-like receptor |
| UniProt Gene Name: | KIR3DS1 |
| UniProt Entry Name: | KI3S1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using KIR3DS1 antibody (CAB9936) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunohistochemistry of paraffin-embedded human liver using KIR3DS1 antibody (CAB9936) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human mammary cancer using KIR3DS1 antibody (CAB9936) at dilution of 1:100 (40x lens). |
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