Anti-KCNK10 Antibody (CAB11696)
- SKU:
- CAB11696
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-KCNK10 Antibody |
| 抗体コード: | CAB11696 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 384-543 of human KCNK10 (NP_612191.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | U-87MG, HT-29 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 384-543 of human KCNK10 (NP_612191.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | RLGL DQRA HSLD MLSP EKRS VFAA LDTG RFKA SSQE SINN RPNN LRLK GPEQ LNKH GQGA SEDN IINK FGST SRLT KRKN KDLK KTLP EDVQ KIYK TFRN YSLD EEKK EEET EKMC NSDN SSTA MLTD CIQQ HAEL ENGM IPTD TKDR EPEN NSLL EDRN |
| 遺伝子ID: | 54207 |
| Uniprot: | P57789 |
| セルラーロケーション: | Membrane, Multi-pass membrane protein |
| 計算された分子量: | 59kDa/60kDa |
| 観察された分子量: | 70kDa |
| 同義語: | KCNK10, K2p10.1, PPP1R97, TREK-2, TREK2 |
| バックグラウンド: | The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. |
| UniProt Protein Function: | TREK-2: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Channel, potassium; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 14q31.3 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:potassium channel activity; potassium ion leak channel activity; voltage-gated ion channel activity Biological Process: memory; signal transduction; stabilization of membrane potential; synaptic transmission; transport |
| NCBI Summary: | The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008] |
| UniProt Code: | P57789 |
| NCBI GenInfo Identifier: | 13431412 |
| NCBI Gene ID: | 54207 |
| NCBI Accession: | P57789.1 |
| UniProt Secondary Accession: | P57789,Q6B014, Q8TDK7, Q8TDK8, Q9HB59, B2R8T4, B2RCT3 B5TJL4, |
| UniProt Related Accession: | P57789 |
| Molecular Weight: | |
| NCBI Full Name: | Potassium channel subfamily K member 10 |
| NCBI Synonym Full Names: | potassium two pore domain channel subfamily K member 10 |
| NCBI Official Symbol: | KCNK10 |
| NCBI Official Synonym Symbols: | TREK2; TREK-2; K2p10.1; PPP1R97 |
| NCBI Protein Information: | potassium channel subfamily K member 10 |
| UniProt Protein Name: | Potassium channel subfamily K member 10 |
| UniProt Synonym Protein Names: | Outward rectifying potassium channel protein TREK-2; TREK-2 K(+) channel subunit |
| Protein Family: | Potassium channel subfamily |
| UniProt Gene Name: | KCNK10 |
| UniProt Entry Name: | KCNKA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using KCNK10 antibody (CAB11696) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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