Anti-KAT6A Antibody (CAB15006)
- SKU:
- CAB15006
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-KAT6A Antibody |
| 抗体コード: | CAB15006 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 800-1000 of human KAT6A (NP_001092883.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 293T |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 800-1000 of human KAT6A (NP_001092883.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | EEPQ CQER ELEI SVGK SVSH ENKE QDSY SVES EKKP EVMA PVSS TRLS KQVL PHDS LPAN SQPS RRGR WGRK NRKT QERF GDKD SKLL LEET SSAP QEQY GECG EKSE ATQE QYTE SEEQ LVAS EEQP SQDG KPDL PKRR LSEG VEPW RGQL KKSP EALK CRLT EGSE RLPR RYSE GDRA VLRG FSES SEEE EEPE SPRS S |
| 遺伝子ID: | 7994 |
| Uniprot: | Q92794 |
| セルラーロケーション: | Nucleus, PML body, nucleolus, nucleoplasm |
| 計算された分子量: | 225kDa |
| 観察された分子量: | 250kDa |
| 同義語: | KAT6A, MOZ, MRD32, MYST-3, MYST3, RUNXBP2, ZC2HC6A, ZNF220 |
| バックグラウンド: | This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain. It is part of a complex that acetylates lysine-9 residues in histone 3, and in addition, it acts as a co-activator for several transcription factors. Allelic variants of this gene are associated with autosomal dominant mental retardation-32. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | MYST3: Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Chromosomal aberrations involving KAT6A may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with CREBBP; translocation t(8;22)(p11;q13) with EP300. KAT6A- CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation. A chromosomal aberration involving KAT6A is a cause of therapy-related myelodysplastic syndrome. Translocation t(2;8)(p23;p11.2) with ASXL2 generates a KAT6A-ASXL2 fusion protein. Belongs to the MYST (SAS/MOZ) family. |
| UniProt Protein Details: | Protein type:Acetyltransferase; EC 2.3.1.48; Oncoprotein; Nucleolus Chromosomal Location of Human Ortholog: 8p11 Cellular Component: Golgi apparatus; nucleoplasm; nucleus; PML body Molecular Function:acetyltransferase activity; DNA binding; histone acetyltransferase activity; protein binding; transcription coactivator activity; transcription factor binding; zinc ion binding Biological Process: DNA packaging; histone acetylation; myeloid cell differentiation; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; protein amino acid acetylation Disease: Mental Retardation, Autosomal Dominant 32 |
| NCBI Summary: | This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain. It is part of a complex that acetylates lysine-9 residues in histone 3, and in addition, it acts as a co-activator for several transcription factors. Allelic variants of this gene are associated with autosomal dominant mental retardation-32. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] |
| UniProt Code: | Q92794 |
| NCBI GenInfo Identifier: | 215274095 |
| NCBI Gene ID: | 7994 |
| NCBI Accession: | Q92794.2 |
| UniProt Secondary Accession: | Q92794,Q76L81, |
| UniProt Related Accession: | Q92794 |
| Molecular Weight: | 225,028 Da |
| NCBI Full Name: | Histone acetyltransferase KAT6A |
| NCBI Synonym Full Names: | lysine acetyltransferase 6A |
| NCBI Official Symbol: | KAT6A |
| NCBI Official Synonym Symbols: | MOZ; MRD32; MYST3; MYST-3; ZNF220; RUNXBP2; ZC2HC6A |
| NCBI Protein Information: | histone acetyltransferase KAT6A |
| UniProt Protein Name: | Histone acetyltransferase KAT6A |
| UniProt Synonym Protein Names: | MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3; MYST-3; Monocytic leukemia zinc finger protein; Runt-related transcription factor-binding protein 2; Zinc finger protein 220 |
| Protein Family: | Histone acetyltransferase |
| UniProt Gene Name: | KAT6A |
| UniProt Entry Name: | KAT6A_HUMAN |
 | Western blot analysis of extracts of 293T cells, using KAT6A antibody (CAB15006) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunofluorescence analysis of NIH/3T3 cells using KAT6A antibody (CAB15006) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of U2OS cells using KAT6A antibody (CAB15006) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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