| 同義語: | KAT5, ESA1, HTATIP, HTATIP1, PLIP, TIP, TIP60, ZC2HC5, cPLA2 |
| UniProt Protein Function: | Tip60: a histone acetyl transferase (HAT) of the MYST family. Originally isolated as an HIV-1 TAT-interactive protein. Plays an important role in regulating chromatin remodeling, transcription and other nuclear processes by acetylating nuclear proteins. Plays a role in DNA repair and apoptosis. Three splice variants have been described. |
| UniProt Protein Details: | Protein type:Acetyltransferase; Nucleolus; Nuclear receptor co-regulator; EC 2.3.1.48 Chromosomal Location of Human Ortholog: 11q13 Cellular Component: NuA4 histone acetyltransferase complex; nucleolus; nucleoplasm; nucleus Molecular Function:acetyltransferase activity; histone acetyltransferase activity; protein binding; transcription coactivator activity Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; DNA double-strand break processing; DNA replication; DNA synthesis during DNA repair; double-strand break repair; double-strand break repair via nonhomologous end joining; histone acetylation; negative regulation of interleukin-2 production; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; proteasomal ubiquitin-dependent protein catabolic process; response to ionizing radiation; strand displacement |
| NCBI Summary: | The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q92993 |
| NCBI GenInfo Identifier: | 30923328 |
| NCBI Gene ID: | 10524 |
| NCBI Accession: | Q92993.2 |
| UniProt Secondary Accession: | Q92993,O95624, Q13430, Q17RW5, Q561W3, Q6GSE8, Q9BWK7 B4E3C7, C9JL99, |
| UniProt Related Accession: | Q92993 |
| Molecular Weight: | 56,292 Da |
| NCBI Full Name: | Histone acetyltransferase KAT5 |
| NCBI Synonym Full Names: | lysine acetyltransferase 5 |
| NCBI Official Symbol: | KAT5 |
| NCBI Official Synonym Symbols: | TIP; ESA1; PLIP; TIP60; cPLA2; HTATIP; ZC2HC5; HTATIP1 |
| NCBI Protein Information: | histone acetyltransferase KAT5 |
| UniProt Protein Name: | Histone acetyltransferase KAT5 |
| UniProt Synonym Protein Names: | 60 kDa Tat-interactive protein; Tip60; Histone acetyltransferase HTATIP; HIV-1 Tat interactive protein; Lysine acetyltransferase 5; cPLA(2)-interacting protein |
| Protein Family: | 3-ketoacyl-CoA thiolase |
| UniProt Gene Name: | KAT5 |
| UniProt Entry Name: | KAT5_HUMAN |
