Anti-ITPR3 Antibody (CAB12794)
- SKU:
- CAB12794
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| 抗体名: | Anti-ITPR3 Antibody |
| 抗体コード: | CAB12794 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1630-1870 of human ITPR3 (NP_002215.2). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | HeLa, LO2, HepG2 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1630-1870 of human ITPR3 (NP_002215.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | EGSE AYQR CESG GFLS KLIQ HTKD LMES EEKL CIKV LRTL QQML LKKT KYGD RGNQ LRKM LLQN YLQN RKST SRGD LPDP IGTG LDPD WSAI AATQ CRLD KEGA TKLV CDLI TSTK NEKI FQES IGLA IHLL DGGN TEIQ KSFH NLMM SDKK SERF FKVL HDRM KRAQ QETK STVA VNMN DLGS QPHE DREP VDPT TKGR VASF SIPG SSSR YSLG PSLR RGHE VSER VQSS EMGT SVLI M |
| 遺伝子ID: | 3710 |
| Uniprot: | Q14573 |
| セルラーロケーション: | Endoplasmic reticulum membrane, Multi-pass membrane protein |
| 計算された分子量: | 304kDa |
| 観察された分子量: | 300kDa |
| 同義語: | ITPR3, IP3R, IP3R3 |
| バックグラウンド: | This gene encodes a receptor for inositol 1, 4, 5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1, 4, 5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. |
| UniProt Protein Function: | JAG1: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Interacts with NOTCH2 and NOTCH3. Interacts with NOTCH1 (in the presence of calcium ions). Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 20p12.1-p11.23 Cellular Component: membrane; apical part of cell; integral to plasma membrane; extracellular region; plasma membrane Molecular Function:protein binding; growth factor activity; calcium ion binding; structural molecule activity; Notch binding Biological Process: endothelial cell differentiation; nervous system development; Notch signaling pathway; positive regulation of myeloid cell differentiation; T cell mediated immunity; Notch receptor processing; auditory receptor cell differentiation; cell fate determination; negative regulation of fat cell differentiation; regulation of cell migration; regulation of cell proliferation; keratinocyte differentiation; myoblast differentiation; positive regulation of osteoblast differentiation; negative regulation of neuron differentiation; response to muramyl dipeptide; morphogenesis of an epithelial sheet; positive regulation of transcription from RNA polymerase II promoter; hemopoiesis; blood vessel remodeling; angiogenesis; positive regulation of Notch signaling pathway Disease: Tetralogy Of Fallot; Alagille Syndrome 1 |
| NCBI Summary: | This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010] |
| UniProt Code: | Q14573 |
| NCBI GenInfo Identifier: | 153945846 |
| NCBI Gene ID: | 3710 |
| NCBI Accession: | NP_002215 |
| UniProt Related Accession: | Q14573 |
| Molecular Weight: | |
| NCBI Full Name: | inositol 1,4,5-trisphosphate receptor type 3 |
| NCBI Synonym Full Names: | inositol 1,4,5-trisphosphate receptor type 3 |
| NCBI Official Symbol: | ITPR3 |
| NCBI Official Synonym Symbols: | IP3R; IP3R3 |
| NCBI Protein Information: | inositol 1,4,5-trisphosphate receptor type 3 |
| UniProt Protein Name: | Protein jagged-1 |
| UniProt Synonym Protein Names: | CD_antigen: CD339 |
| Protein Family: | Protein jagged |
| UniProt Gene Name: | JAG1 |
| UniProt Entry Name: | JAG1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ITPR3 antibody (CAB12794) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of NIH-3T3 cells using ITPR3 antibody (CAB12794) at dilution of 1:100. Blue: DAPI for nuclear staining. |