| UniProt Protein Function: | IRX3: Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Belongs to the TALE/IRO homeobox family. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 16q12.2 |
| NCBI Summary: | IRX3 is a member of the Iroquois homeobox gene family (see IRX1; MIM 606197) and plays a role in an early step of neural development (Bellefroid et al., 1998 [PubMed 9427753]). Members of this family appear to play multiple roles during pattern formation of vertebrate embryos (Lewis et al., 1999 [PubMed 10370142]).[supplied by OMIM, Aug 2009] |
| UniProt Code: | P78415 |
| NCBI GenInfo Identifier: | 47117874 |
| NCBI Gene ID: | 79191 |
| NCBI Accession: | P78415.3 |
| UniProt Secondary Accession: | P78415,Q7Z4A4, Q7Z4A5, Q8IVC6, |
| UniProt Related Accession: | P78415 |
| Molecular Weight: | 52,119 Da |
| NCBI Full Name: | Iroquois-class homeodomain protein IRX-3 |
| NCBI Synonym Full Names: | iroquois homeobox 3 |
| NCBI Official Symbol: | IRX3 |
| NCBI Official Synonym Symbols: | IRX-1; IRXB1 |
| NCBI Protein Information: | iroquois-class homeodomain protein IRX-3 |
| UniProt Protein Name: | Iroquois-class homeodomain protein IRX-3 |
| UniProt Synonym Protein Names: | Homeodomain protein IRXB1; Iroquois homeobox protein 3 |
| Protein Family: | Iroquois-class homeodomain protein |
| UniProt Gene Name: | IRX3 |
| UniProt Entry Name: | IRX3_HUMAN |
