Anti-IQWD1 Antibody (CAB14286)
- SKU:
- CAB14286
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-IQWD1 Antibody |
| 抗体コード: | CAB14286 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 460-650 of human IQWD1 (NP_001017977.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | HeLa, LO2 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 460-650 of human IQWD1 (NP_001017977.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | DNNN EKLS PKPG TGEP VLSL HYST EGTT TSTI KLNF TDEW SSIA SSSR GIGS HCKS EGQE ESFV PQSS VQPP EGDS ETKA PEES SEDV TKYQ EGVS AENP VENH INIT QSDK FTAK PLDS NSGE RNDL NLDR SCGV PEES ASSE KAKE PETS DQTS TESA TNEN NTNP EPQF QTEA TGPS AHEE TSTR DSA |
| 遺伝子ID: | 55827 |
| Uniprot: | Q58WW2 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 96kDa/98kDa/103kDa/106kDa |
| 観察された分子量: | 105kDa |
| 同義語: | DCAF6, 1200006M05Rik, ARCAP, IQWD1, MSTP055, NRIP, PC326 |
| バックグラウンド: | The protein encoded by this gene is a ligand-dependent coactivator of nuclear receptors, including nuclear receptor subfamily 3 group C member 1 (NR3C1), glucocorticoid receptor (GR), and androgen receptor (AR). The encoded protein and DNA damage binding protein 2 (DDB2) may act as tumor promoters and tumor suppressors, respectively, by regulating the level of androgen receptor in prostate tissues. In addition, this protein can act with glucocorticoid receptor to promote human papillomavirus gene expression. |
| UniProt Protein Function: | MSTP055: Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 1q24.2 Cellular Component: nucleoplasm; focal adhesion; cytoplasm; nucleus Molecular Function:ligand-dependent nuclear receptor transcription coactivator activity Biological Process: protein ubiquitination; positive regulation of transcription from RNA polymerase II promoter |
| UniProt Code: | Q58WW2 |
| NCBI GenInfo Identifier: | 74755134 |
| NCBI Gene ID: | 55827 |
| NCBI Accession: | Q58WW2.1 |
| UniProt Secondary Accession: | Q58WW2,Q7L8I0, Q8IXH3, Q8TB19, A2A295, B4DNB8, |
| UniProt Related Accession: | Q58WW2 |
| Molecular Weight: | 103,070 Da |
| NCBI Full Name: | DDB1- and CUL4-associated factor 6 |
| NCBI Synonym Full Names: | DDB1 and CUL4 associated factor 6 |
| NCBI Official Symbol: | DCAF6 |
| NCBI Official Synonym Symbols: | NRIP; ARCAP; IQWD1; PC326; MSTP055; 1200006M05Rik |
| NCBI Protein Information: | DDB1- and CUL4-associated factor 6; IQ motif and WD repeat-containing protein 1; IQ motif and WD repeats 1; androgen receptor complex-associated protein; nuclear receptor interaction protein |
| UniProt Protein Name: | DDB1- and CUL4-associated factor 6 |
| UniProt Synonym Protein Names: | Androgen receptor complex-associated protein; ARCAP; IQ motif and WD repeat-containing protein 1; Nuclear receptor interaction protein; NRIP |
| Protein Family: | DDB1- and CUL4-associated factor |
| UniProt Gene Name: | DCAF6 |
| UniProt Entry Name: | DCAF6_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IQWD1 antibody (CAB14286) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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