Anti-INSRR Antibody (CAB10083)
- SKU:
- CAB10083
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-INSRR Antibody |
| 抗体コード: | CAB10083 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 747-921 of human INSRR (NP_055030.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:1000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Mouse brain, Mouse liver, Mouse kidney, Rat kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 747-921 of human INSRR (NP_055030.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | AAGP LRLG GNSS DFEI QEDK VPRE RAVL SGLR HFTE YRID IHAC NHAA HTVG CSAA TFVF ARTM PHRE ADGI PGKV AWEA SSKN SVLL RWLE PPDP NGLI LKYE IKYR RLGE EATV LCVS RLRY AKFG GVHL ALLP PGNY SARV RATS LAGN GSWT DSVA FYIL GPEE EDAG GLH |
| 遺伝子ID: | 3645 |
| Uniprot: | P14616 |
| セルラーロケーション: | Membrane, Single-pass type I membrane protein |
| 計算された分子量: | 143kDa |
| 観察された分子量: | 105kDa |
| 同義語: | INSRR, IRR |
| バックグラウンド: |
| UniProt Protein Function: | IRR: Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. |
| UniProt Protein Details: | Protein type:Protein kinase, TK; Membrane protein, integral; Kinase, protein; Protein kinase, tyrosine (receptor); EC 2.7.10.1; TK group; InsR family Chromosomal Location of Human Ortholog: 1q21-q23 Cellular Component: integral to plasma membrane; receptor complex Molecular Function:insulin receptor substrate binding; phosphoinositide 3-kinase binding; transmembrane receptor protein tyrosine kinase activity; ATP binding Biological Process: peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; male sex determination; actin cytoskeleton reorganization; transmembrane receptor protein tyrosine kinase signaling pathway |
| UniProt Code: | P14616 |
| NCBI GenInfo Identifier: | 31657140 |
| NCBI Gene ID: | 3645 |
| NCBI Accession: | NP_055030.1 |
| UniProt Secondary Accession: | P14616,O60724, Q5VZS3, |
| UniProt Related Accession: | P14616 |
| Molecular Weight: | 143,720 Da |
| NCBI Full Name: | insulin receptor-related protein |
| NCBI Synonym Full Names: | insulin receptor-related receptor |
| NCBI Official Symbol: | INSRR |
| NCBI Official Synonym Symbols: | IRR |
| NCBI Protein Information: | insulin receptor-related protein; IR-related receptor |
| UniProt Protein Name: | Insulin receptor-related protein |
| UniProt Synonym Protein Names: | IR-related receptor |
| Protein Family: | Insulin receptor-related protein |
| UniProt Gene Name: | INSRR |
| UniProt Entry Name: | INSRR_HUMAN |
 | Western blot analysis of extracts of various cell lines, using INSRR antibody (CAB10083) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s. |
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