Anti-IFNGR2 Antibody (CAB14221)
- SKU:
- CAB14221
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-IFNGR2 Antibody |
| 抗体コード: | CAB14221 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human IFNGR2 (NP_005525.2). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | A-549, HepG2, Rat heart |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human IFNGR2 (NP_005525.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | DNLK PSRV YCLQ VQAQ LLWN KSNI FRVG HLSN ISCY ETMA DAST ELQQ VILI SVGT FSLL SVLA GACF FLVL KYRG LIKY WFHT PPSI PLQI EEYL KDPT QPIL EALD KDSS PKDD VWDS VSII SFPE KEQE DVLQ TL |
| 遺伝子ID: | 3460 |
| Uniprot: | P38484 |
| セルラーロケーション: | Membrane, Single-pass type I membrane protein |
| 計算された分子量: | 37kDa |
| 観察された分子量: | 38kDa |
| 同義語: | IFNGR2, AF-1, IFGR2, IFNGT1, IMD28 |
| バックグラウンド: | This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. |
| UniProt Protein Function: | IFNGR2: Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD); also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. Belongs to the type II cytokine receptor family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 21q22.11 Cellular Component: integral to plasma membrane; endoplasmic reticulum; integral to membrane; plasma membrane Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interferon-gamma receptor activity Biological Process: cell surface receptor linked signal transduction; response to virus; cytokine and chemokine mediated signaling pathway Disease: Immunodeficiency 28 |
| NCBI Summary: | This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P38484 |
| NCBI GenInfo Identifier: | 145559548 |
| NCBI Gene ID: | 3460 |
| NCBI Accession: | P38484.2 |
| UniProt Secondary Accession: | P38484,Q9BTL5, |
| UniProt Related Accession: | P38484 |
| Molecular Weight: | 337 |
| NCBI Full Name: | Interferon gamma receptor 2 |
| NCBI Synonym Full Names: | interferon gamma receptor 2 (interferon gamma transducer 1) |
| NCBI Official Symbol: | IFNGR2 |
| NCBI Official Synonym Symbols: | AF-1; IFGR2; IMD28; IFNGT1 |
| NCBI Protein Information: | interferon gamma receptor 2; IFN-gamma-R2; IFN-gamma receptor 2; interferon gamma transducer 1; interferon gamma receptor beta chain; interferon gamma receptor accessory factor 1; interferon gamma receptor accessory factor-1 |
| UniProt Protein Name: | Interferon gamma receptor 2 |
| UniProt Synonym Protein Names: | Interferon gamma receptor accessory factor 1; AF-1; Interferon gamma transducer 1 |
| Protein Family: | Interferon gamma receptor |
| UniProt Gene Name: | IFNGR2 |
| UniProt Entry Name: | INGR2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IFNGR2 Rabbit pAb (CAB14221) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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