Anti-IFNGR1 Antibody (CAB11653)
- SKU:
- CAB11653
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-IFNGR1 Antibody |
| 抗体コード: | CAB11653 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthesized peptide derived from human IFNGR1 |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa, 293T, BxPC-3, Mouse liver, Mouse spleen, Mouse thymus, Rat liver |
| 免疫原: | A synthesized peptide derived from human IFNGR1 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 3459 |
| Uniprot: | P15260 |
| セルラーロケーション: | |
| 計算された分子量: | 45-100kDa |
| 観察された分子量: | 40-100KDa |
 | Western blot - IFNGR1 Rabbit mAb (CAB11653) |
| 同義語: | CD119, IFNGR, IMD27A, IMD27B |
| バックグラウンド: | This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | IFNGR1: Receptor for interferon gamma. Two receptors bind one interferon gamma dimer. Defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD); also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. Belongs to the type II cytokine receptor family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, cytokine Chromosomal Location of Human Ortholog: 6q23.3 Cellular Component: integral to plasma membrane; endoplasmic reticulum; dendrite; postsynaptic density; plasma membrane; integral to membrane; vesicle Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; interferon-gamma receptor activity; cytokine binding Biological Process: cytokine and chemokine mediated signaling pathway; response to virus; signal transduction Disease: Helicobacter Pylori Infection, Susceptibility To; Immunodeficiency 27b; Immunodeficiency 27a; Mycobacterium Tuberculosis, Susceptibility To; Hepatitis B Virus, Susceptibility To |
| NCBI Summary: | This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P15260 |
| NCBI GenInfo Identifier: | 124474 |
| NCBI Gene ID: | 3459 |
| NCBI Accession: | P15260.1 |
| UniProt Secondary Accession: | P15260,Q53Y96, B4DFT7, E1P587, |
| UniProt Related Accession: | P15260 |
| Molecular Weight: | Calculated: 21kDa/54kDaObserved: 70kDa |
| NCBI Full Name: | Interferon gamma receptor 1 |
| NCBI Synonym Full Names: | interferon gamma receptor 1 |
| NCBI Official Symbol: | IFNGR1 |
| NCBI Official Synonym Symbols: | CD119; IFNGR; IMD27A; IMD27B |
| NCBI Protein Information: | interferon gamma receptor 1; CDw119; AVP, type 2; IFN-gamma-R1; CD119 antigen; IFN-gamma receptor 1; antiviral protein, type 2; immune interferon receptor 1; interferon-gamma receptor alpha chain |
| UniProt Protein Name: | Interferon gamma receptor 1 |
| UniProt Synonym Protein Names: | CDw119; CD_antigen: CD119 |
| Protein Family: | Interferon gamma receptor |
| UniProt Gene Name: | IFNGR1 |
| UniProt Entry Name: | INGR1_HUMAN |