Anti-IFIT3 Antibody (CAB3924)
- SKU:
- CAB3924
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-IFIT3 Antibody |
| 抗体コード: | CAB3924 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 128-331 of mouse IFIT3 (NP_034631.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:1000 IHC 1:100 - 1:200 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse kidney, Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 128-331 of mouse IFIT3 (NP_034631.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | ANPY SMEC PELE CEEG WTRL KCGR NERA KMCF EKAL EEKP KDPE CSSG MAIA MFRL EEKP EKQF SVDA LKQA MELN PQNQ YLKV LLAL KLLR MGEE AEGE RLIK DALG KAPN QTDV LQKA AQFY KKKG NLDR AIEL LGKA LRST VNNS PLYS LVMC RYRE ILEQ LQNK GDAD SSER RQRM AELR RLTM EFMQ KTLQ RRRS PLNS |
| 遺伝子ID: | 15959 |
| Uniprot: | O14879 |
| セルラーロケーション: | Cytoplasm, Mitochondrion |
| 計算された分子量: | 47kDa |
| 観察された分子量: | 60kDa |
| 同義語: | IFIT3, CIG-49, GARG-49, IFI60, IFIT4, IRG2, ISG60, P60, RIG-G, cig41 |
| バックグラウンド: |
| UniProt Protein Function: | IFIT3: IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS- mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin- dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2. Belongs to the IFIT family. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 10q24 Cellular Component: mitochondrion; cytoplasm; cytosol Molecular Function:identical protein binding; protein binding Biological Process: negative regulation of cell proliferation; cytokine and chemokine mediated signaling pathway; response to virus; defense response to virus; negative regulation of apoptosis |
| UniProt Code: | O14879 |
| NCBI GenInfo Identifier: | 6831570 |
| NCBI Gene ID: | 3437 |
| NCBI Accession: | O14879.1 |
| UniProt Secondary Accession: | O14879,Q99634, Q9BSK7, |
| UniProt Related Accession: | O14879 |
| Molecular Weight: | 490 |
| NCBI Full Name: | Interferon-induced protein with tetratricopeptide repeats 3 |
| NCBI Synonym Full Names: | interferon-induced protein with tetratricopeptide repeats 3 |
| NCBI Official Symbol: | IFIT3 |
| NCBI Official Synonym Symbols: | P60; IRG2; IFI60; IFIT4; ISG60; RIG-G; CIG-49; GARG-49 |
| NCBI Protein Information: | interferon-induced protein with tetratricopeptide repeats 3; CIG49; IFIT-3; IFIT-4; ISG-60; IFI-60K; interferon-induced 60 kDa protein; retinoic acid-induced gene G protein; interferon-induced protein with tetratricopeptide repeats 4 |
| UniProt Protein Name: | Interferon-induced protein with tetratricopeptide repeats 3 |
| UniProt Synonym Protein Names: | CIG49; ISG-60; Interferon-induced 60 kDa protein; IFI-60K; Interferon-induced protein with tetratricopeptide repeats 4; IFIT-4; Retinoic acid-induced gene G protein; P60; RIG-G |
| Protein Family: | Interferon-induced protein with tetratricopeptide repeats |
| UniProt Gene Name: | IFIT3 |
| UniProt Entry Name: | IFIT3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IFIT3 antibody (CAB3924) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s. |
 | Immunohistochemistry of paraffin-embedded human lung cancer using IFIT3 antibody (CAB3924) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human liver using IFIT3 antibody (CAB3924) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of U2OS cells using IFIT3 antibody (CAB3924) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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