Anti-ICAM4 Antibody (CAB7438)
- SKU:
- CAB7438
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-ICAM4 Antibody |
| 抗体コード: | CAB7438 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-140 of human ICAM4 (NP_001034221.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HepG2, Jurkat, SW480, Mouse brain, Mouse spleen, Mouse heart, Mouse pancreas, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-140 of human ICAM4 (NP_001034221.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VGSA LGRR TKRA QSPK GSPL APSG TSVP FWVR MSPE FVAV QPGK SVQL NCSN SCPQ PQNS SLRT PLRQ GKTL RGPG WVSY QLLD VRAW SSLA HCLV TCAG KTRW ATSR ITAY SVPG GLLG G |
| 遺伝子ID: | 3386 |
| Uniprot: | Q14773 |
| セルラーロケーション: | Cell membrane, Secreted, Single-pass type I membrane protein |
| 計算された分子量: | 25kDa/29kDa |
| 観察された分子量: | 29kDa |
| 同義語: | ICAM4, CD242, LW |
| バックグラウンド: | This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
| UniProt Protein Function: | ICAM4: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins. Belongs to the immunoglobulin superfamily. ICAM family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 19p13.2-cen Disease: Blood Group System, Landsteiner-wiener |
| NCBI Summary: | This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14773 |
| NCBI GenInfo Identifier: | 2497309 |
| NCBI Gene ID: | 3386 |
| NCBI Accession: | Q14773.1 |
| UniProt Secondary Accession: | Q14773,Q14771, Q14772, Q16375, Q9BWR0, A0M8X2, |
| UniProt Related Accession: | Q14773 |
| Molecular Weight: | 271 |
| NCBI Full Name: | Intercellular adhesion molecule 4 |
| NCBI Synonym Full Names: | intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) |
| NCBI Official Symbol: | ICAM4 |
| NCBI Official Synonym Symbols: | LW; CD242 |
| NCBI Protein Information: | intercellular adhesion molecule 4; CD242 antigen; LW blood group protein; Landsteiner-Wiener blood group antigen a; Landsteiner-Wiener blood group glycoprotein; intercellular adhesion molecule 4 (LW blood group); intercellular adhesion molecule 4 isoform 3 anitgen LWa |
| UniProt Protein Name: | Intercellular adhesion molecule 4 |
| UniProt Synonym Protein Names: | Landsteiner-Wiener blood group glycoprotein; LW blood group protein; CD_antigen: CD242 |
| Protein Family: | Intercellular adhesion molecule |
| UniProt Gene Name: | ICAM4 |
| UniProt Entry Name: | ICAM4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ICAM4 antibody (CAB7438) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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