Anti-HYAL1 Antibody (CAB6623)
- SKU:
- CAB6623
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-HYAL1 Antibody |
| 抗体コード: | CAB6623 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 136-435 of human HYAL1 (NP_149349.2). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse liver, Mouse lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 136-435 of human HYAL1 (NP_149349.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | RWAF NWDT KDIY RQRS RALV QAQH PDWP APQV EAVA QDQF QGAA RAWM AGTL QLGR ALRP RGLW GFYG FPDC YNYD FLSP NYTG QCPS GIRA QNDQ LGWL WGQS RALY PSIY MPAV LEGT GKSQ MYVQ HRVA EAFR VAVA AGDP NLPV LPYV QIFY DTTN HFLP LDEL EHSL GESA AQGA AGVV LWVS WENT RTKE SCQA IKEY MDTT LGPF ILNV TSGA LLCS QALC SGHG RCVR RTSH PKAL LLLN PASF SIQL TPGG GPLS LRGA LSLE DQAQ MAVE FKCR CYPG WQAP WCER KSMW |
| 遺伝子ID: | 3373 |
| Uniprot: | Q12794 |
| セルラーロケーション: | Lysosome, Secreted |
| 計算された分子量: | 10kDa/19kDa/23kDa/27kDa/37kDa/45kDa/48kDa |
| 観察された分子量: | 48kDa |
| 同義語: | HYAL1, HYAL-1, LUCA1, MPS9, NAT6 |
| バックグラウンド: | This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | HYAL1: May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. Defects in HYAL1 are the cause of mucopolysaccharidosis type 9 (MPS9); also called hyaluronidase deficiency. MPS9 is a lysosomal storage disease characterized by high hyaluronan (HA) concentration in the serum. The clinical features are periarticular soft tissue masses, mild short stature and acetabular erosions, and absence of neurological or visceral involvement. Belongs to the glycosyl hydrolase 56 family. 7 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.2.1.35; Glycan Metabolism - glycosaminoglycan degradation; Secreted, signal peptide; Secreted; Hydrolase Chromosomal Location of Human Ortholog: 3p21.31 Cellular Component: extracellular space; lysosomal lumen; lysosome; cytoplasm; cytoplasmic vesicle Molecular Function:viral receptor activity; hyaluronan synthase activity; transcription factor binding; hyalurononglucosaminidase activity Biological Process: positive regulation of cell adhesion; glycosaminoglycan metabolic process; response to virus; pathogenesis; positive regulation of cell growth; hyaluronan catabolic process; response to antibiotic; chondroitin sulfate metabolic process; positive regulation of angiogenesis; response to reactive oxygen species; hyaluronan biosynthetic process; cartilage development; carbohydrate metabolic process; chondroitin sulfate catabolic process; negative regulation of cell growth; inflammatory response; hyaluronan metabolic process; positive regulation of growth; positive regulation of epithelial cell proliferation Disease: Mucopolysaccharidosis, Type Ix |
| NCBI Summary: | This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q12794 |
| NCBI GenInfo Identifier: | 74735617 |
| NCBI Gene ID: | 3373 |
| NCBI Accession: | Q12794.2 |
| UniProt Related Accession: | Q12794 |
| Molecular Weight: | |
| NCBI Full Name: | Hyaluronidase-1 |
| NCBI Synonym Full Names: | hyaluronidase 1 |
| NCBI Official Symbol: | HYAL1 |
| NCBI Official Synonym Symbols: | MPS9; NAT6; LUCA1; HYAL-1 |
| NCBI Protein Information: | hyaluronidase-1 |
| UniProt Protein Name: | Hyaluronidase-1 |
| UniProt Synonym Protein Names: | Hyaluronoglucosaminidase-1; Lung carcinoma protein 1; LuCa-1 |
| UniProt Gene Name: | HYAL1 |
| UniProt Entry Name: | HYAL1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using HYAL1 Antibody (CAB6623) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human stomach using HYAL1 antibody (CAB6623) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat kidney using HYAL1 antibody (CAB6623) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse heart using HYAL1 antibody (CAB6623) at dilution of 1:100 (40x lens). |
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