Anti-HPSE2 Antibody (CAB8248)
- SKU:
- CAB8248
- Product type:
- Antibody
- Application:
- WB
- Application:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | HPSE2 Rabbit Polyclonal Antibody |
抗体コード: | CAB8248 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 42-242 of human HPSE2 (NP_068600.4). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | BT-474, 22Rv1, HeLa, SKOV3, Mouse brain, Mouse small intestine, Mouse testis, Mouse uterus, Rat brain |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 42-242 of human HPSE2 (NP_068600.4). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | GDRR PLPV DRAA GLKE KTLI LLDV STKN PVRT VNEN FLSL QLDP SIIH DGWL DFLS SKRL VTLA RGLS PAFL RFGG KRTD FLQF QNLR NPAK SRGG PGPD YYLK NYED DIVR SDVA LDKQ KGCK IAQH PDVM LELQ REKA AQMH LVLL KEQF SNTY SNLI LTAR SLDK LYNF ADCS GLHL IFAL NALR RNPN NSWN SSSA L |
遺伝子ID: | 60495 |
Uniprot: | Q8WWQ2 |
セルラーロケーション: | Secreted, extracellular matrix, extracellular space |
計算された分子量: | 53kDa/60kDa/61kDa/66kDa |
観察された分子量: | 72kDa |
同義語: | HPSE2, HPA2, HPR2, UFS, UFS1 |
バックグラウンド: | This gene encodes a heparanase enzyme. The encoded protein is a endoglycosidase that degrades heparin sulfate proteoglycans located on the extracellular matrix and cell surface. This protein may be involved in biological processes involving remodeling of the extracellular matrix including angiogenesis and tumor progression. Alternate splicing results in multiple transcript variants. |
UniProt Protein Function: | HPSE2: Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro). Defects in HPSE2 are the cause of urofacial syndrome (UFS). A rare autosomal recessive characterized by facial grimacing when attempting to smile and failure of the urinary bladder to void completely despite a lack of anatomical bladder outflow obstruction or overt neurological damage. Affected individuals often have reflux of infected urine from the bladder to the upper renal tract, with a risk of kidney damage and renal failure. Belongs to the glycosyl hydrolase 79 family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.2.-.-; Hydrolase; Glycan Metabolism - glycosaminoglycan degradation Chromosomal Location of Human Ortholog: 10q23-q24 Cellular Component: proteinaceous extracellular matrix; plasma membrane; intracellular Molecular Function:heparan sulfate proteoglycan binding; heparanase activity Biological Process: glycosaminoglycan catabolic process; glycosaminoglycan metabolic process; carbohydrate metabolic process; pathogenesis Disease: Urofacial Syndrome 1 |
NCBI Summary: | This gene encodes a heparanase enzyme. The encoded protein is a endoglycosidase that degrades heparin sulfate proteoglycans located on the extracellular matrix and cell surface. This protein may be involved in biological processes involving remodeling of the extracellular matrix including angiogenesis and tumor progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] |
UniProt Code: | Q8WWQ2 |
NCBI GenInfo Identifier: | 261878501 |
NCBI Gene ID: | 60495 |
NCBI Accession: | NP_068600 |
UniProt Secondary Accession: | Q8WWQ2,Q5VUH4, Q5VUH5, Q5VUH6, Q8WWQ1, Q9HB37, Q9HB38 Q9HB39, |
UniProt Related Accession: | Q8WWQ2 |
Molecular Weight: | 53,917 Da |
NCBI Full Name: | inactive heparanase-2 isoform 1 |
NCBI Synonym Full Names: | heparanase 2 (inactive) |
NCBI Official Symbol: | HPSE2 |
NCBI Official Synonym Symbols: | UFS; HPA2; HPR2; UFS1 |
NCBI Protein Information: | inactive heparanase-2 |
UniProt Protein Name: | Inactive heparanase-2 |
Protein Family: | Histone acetyltransferase |
UniProt Gene Name: | HPSE2 |
UniProt Entry Name: | HPSE2_HUMAN |
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