Anti-HOXA13 Antibody (CAB9564)
- SKU:
- CAB9564
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-HOXA13 Antibody |
| 抗体コード: | CAB9564 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthesized peptide derived from human HOXA13 |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa, 293T, HepG2, Mouse liver, Mouse spleen, Mouse kidney, Rat liver |
| 免疫原: | A synthesized peptide derived from human HOXA13 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 3209 |
| Uniprot: | P31271 |
| セルラーロケーション: | |
| 計算された分子量: | 42kDa |
| 観察された分子量: | 45KDa |
| 同義語: | HOX1, HOX1J |
| バックグラウンド: | In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Expansion of a polyalanine tract in the encoded protein can cause hand-foot-uterus syndrome, also known as hand-foot-genital syndrome. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | HOXA13: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Defects in HOXA13 are the cause of hand-foot-genital syndrome (HFGS); also known as hand-foot-uterus syndrome. The clinical features include small feet with unusually short great toes and abnormal thumbs. Females with the disorder have duplication of the genital tract. Defects in HOXA13 are the cause of Guttmacher syndrome (GUTTS). Guttmacher syndrome is a dominantly inherited combination of distal limb and genital tract abnormalities. It has several features in common with hand-foot- genital syndrome, including hypoplastic first digits and hypospadias. Typical features not seen in hand-foot-genital syndrome include postaxial polydactyly of the hands and uniphalangeal second toes with absent nails. Belongs to the Abd-B homeobox family. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 7p15.2 Cellular Component: intermediate filament cytoskeleton; nucleus Molecular Function:DNA binding Biological Process: skeletal development Disease: Hand-foot-genital Syndrome; Preaxial Deficiency, Postaxial Polydactyly, And Hypospadias |
| NCBI Summary: | In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Expansion of a polyalanine tract in the encoded protein can cause hand-foot-uterus syndrome, also known as hand-foot-genital syndrome. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P31271 |
| NCBI GenInfo Identifier: | 116242513 |
| NCBI Gene ID: | 3209 |
| NCBI Accession: | P31271.3 |
| UniProt Secondary Accession: | P31271,O43371, A4D188, |
| UniProt Related Accession: | P31271 |
| Molecular Weight: | 39,727 Da |
| NCBI Full Name: | Homeobox protein Hox-A13 |
| NCBI Synonym Full Names: | homeobox A13 |
| NCBI Official Symbol: | HOXA13 |
| NCBI Official Synonym Symbols: | HOX1; HOX1J |
| NCBI Protein Information: | homeobox protein Hox-A13 |
| UniProt Protein Name: | Homeobox protein Hox-A13 |
| UniProt Synonym Protein Names: | Homeobox protein Hox-1J |
| Protein Family: | Homeobox protein |
| UniProt Gene Name: | HOXA13 |
| UniProt Entry Name: | HXA13_HUMAN |
 | Western blot - HOXA13 Rabbit mAb (CAB9564) |
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