Anti-HNRNPDL Antibody (CAB10721)
- SKU:
- CAB10721
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-HNRNPDL Antibody |
| 抗体コード: | CAB10721 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 261-420 of human HNRNPDL (NP_112740.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Jurkat, SW620, HepG2, Mouse brain, Mouse testis, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 261-420 of human HNRNPDL (NP_112740.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | NIEL PMDT KTNE RRGF CFIT YTDE EPVK KLLE SRYH QIGS GKCE IKVA QPKE VYRQ QQQQ QKGG RGAA AGGR GGTR GRGR GQGQ NWNQ GFNN YYDQ GYGN YNSA YGGD QNYS GYGG YDYT GYNY GNYG YGQG YADY SGQQ STYG KASR GGGN HQNN YQPY |
| 遺伝子ID: | 9987 |
| Uniprot: | O14979 |
| セルラーロケーション: | Cytoplasm, Nucleus |
| 計算された分子量: | 27kDa/33kDa/46kDa |
| 観察された分子量: | 38kDa |
| 同義語: | HNRNPDL, HNRNP, HNRPDL, JKTBP, JKTBP2, LGMD1G, laAUF1 |
| バックグラウンド: | This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind to RNAs. Three alternatively spliced transcript variants have been described for this gene. One of the variants is probably not translated because the transcript is a candidate for nonsense-mediated mRNA decay. The protein isoforms encoded by this gene are similar to its family member HNRPD. |
| UniProt Protein Function: | hnRNP D-like: Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes. Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter. Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding; RNA processing; RNA-binding Chromosomal Location of Human Ortholog: 4q21.22 Cellular Component: nucleoplasm Molecular Function:protein binding; RNA binding Disease: Limb-girdle Muscular Dystrophy, Type 1g |
| NCBI Summary: | This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind to RNAs. Three alternatively spliced transcript variants have been described for this gene. One of the variants is probably not translated because the transcript is a candidate for nonsense-mediated mRNA decay. The protein isoforms encoded by this gene are similar to its family member HNRPD. [provided by RefSeq, May 2011] |
| UniProt Code: | O14979 |
| NCBI GenInfo Identifier: | 74762096 |
| NCBI Gene ID: | 9987 |
| NCBI Accession: | O14979.3 |
| UniProt Secondary Accession: | O14979,Q6SPF2, Q7KZ74, Q7KZ75, Q96IM0, Q96S43, |
| UniProt Related Accession: | O14979 |
| Molecular Weight: | 46kDa |
| NCBI Full Name: | Heterogeneous nuclear ribonucleoprotein D-like |
| NCBI Synonym Full Names: | heterogeneous nuclear ribonucleoprotein D like |
| NCBI Official Symbol: | HNRNPDL |
| NCBI Official Synonym Symbols: | HNRNP; JKTBP; HNRPDL; JKTBP2; LGMD1G; laAUF1 |
| NCBI Protein Information: | heterogeneous nuclear ribonucleoprotein D-like |
| UniProt Protein Name: | Heterogeneous nuclear ribonucleoprotein D-like |
| UniProt Synonym Protein Names: | AU-rich element RNA-binding factor; JKT41-binding protein; Protein laAUF1 |
| Protein Family: | Heterogeneous nuclear ribonucleoprotein |
| UniProt Gene Name: | HNRNPDL |
 | Western blot analysis of extracts of various cell lines, using HNRNPDL antibody (CAB10721) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunofluorescence analysis of U2OS cells using HNRNPDL antibody (CAB10721) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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