Anti-HDAC10 Antibody (CAB6184)
- SKU:
- CAB6184
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Autophagy
Frequently bought together:
Description
| 抗体名: | Anti-HDAC10 Antibody |
| 抗体コード: | CAB6184 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human HDAC10 (NP_114408.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HepG2, HL-60, 293T, HeLa, Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human HDAC10 (NP_114408.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MGTA LVYH EDMT ATRL LWDD PECE IERP ERLT AALD RLRQ RGLE QRCL RLSA REAS EEEL GLVH SPEY VSLV RETQ VLGK EELQ ALSG QFDA IYFH PSTF HCAR LAAG AGLQ LVDA VLTG AVQN GLAL VRPP GHHG QRAA ANGF CVFN NVAI AAAH AKQK HGLH RILV VDWD VHHG QGIQ YLFE DDPS VLYF SWHR YEHG RFWP FLRE SDAD AVGR GQGL GFTV NLPW NQVG MGNA DYVA |
| 遺伝子ID: | 83933 |
| Uniprot: | Q969S8 |
| セルラーロケーション: | Cytoplasm, Nucleus |
| 計算された分子量: | 43kDa/69kDa/70kDa/71kDa |
| 観察された分子量: | 68kDa |
| 同義語: | HDAC10, HD10 |
| バックグラウンド: | The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | HDAC10: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Belongs to the histone deacetylase family. HD type 2 subfamily. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription factor; Deacetylase; EC 3.5.1.98 Chromosomal Location of Human Ortholog: 22q13.31 Cellular Component: nucleoplasm; histone deacetylase complex; cytoplasm; nucleus Molecular Function:NAD-dependent histone deacetylase activity (H3-K9 specific); protein binding; enzyme binding; NAD-dependent histone deacetylase activity (H3-K14 specific); histone deacetylase binding; protein deacetylase activity; NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity Biological Process: establishment and/or maintenance of chromatin architecture; Notch signaling pathway; transcription, DNA-dependent; regulation of transcription, DNA-dependent; protein amino acid deacetylation; histone deacetylation; chromatin modification; negative regulation of transcription from RNA polymerase II promoter; oligodendrocyte development; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q969S8 |
| NCBI GenInfo Identifier: | 27734403 |
| NCBI Gene ID: | 83933 |
| NCBI Accession: | Q969S8.1 |
| UniProt Secondary Accession: | Q969S8,Q08AP4, Q6STF9, Q96P77, Q96P78, Q9H028, Q9UGX1 Q9UGX2, |
| UniProt Related Accession: | Q969S8 |
| Molecular Weight: | 669 |
| NCBI Full Name: | Histone deacetylase 10 |
| NCBI Synonym Full Names: | histone deacetylase 10 |
| NCBI Official Symbol: | HDAC10 |
| NCBI Official Synonym Symbols: | HD10 |
| NCBI Protein Information: | histone deacetylase 10 |
| UniProt Protein Name: | Histone deacetylase 10 |
| Protein Family: | Histone deacetylase |
| UniProt Gene Name: | HDAC10 |
| UniProt Entry Name: | HDA10_HUMAN |
 | Western blot analysis of extracts of various cell lines, using HDAC10 antibody (CAB6184) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Western blot analysis of extracts of rat liver, using HDAC10 antibody (CAB6184) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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