Anti-GRM4 Antibody (CAB7284)
- SKU:
- CAB7284
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-GRM4 Antibody |
| 抗体コード: | CAB7284 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 33-290 of human GRM4 (NP_000832.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Mouse spinal cord, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 33-290 of human GRM4 (NP_000832.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | KPKG HPHM NSIR IDGD ITLG GLFP VHGR GSEG KPCG ELKK EKGI HRLE AMLF ALDR INND PDLL PNIT LGAR ILDT CSRD THAL EQSL TFVQ ALIE KDGT EVRC GSGG PPII TKPE RVVG VIGA SGSS VSIM VANI LRLF KIPQ ISYA STAP DLSD NSRY DFFS RVVP SDTY QAQA MVDI VRAL KWNY VSTV ASEG SYGE SGVE AFIQ KSRE DGGV CIAQ SVKI PREP KAGE FDKI IRRL LETS NARA VIIF ANED DI |
| 遺伝子ID: | 2914 |
| Uniprot: | Q14833 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 83kDa/86kDa/87kDa/88kDa/101kDa |
| 観察された分子量: | 115kDa |
| 同義語: | GRM4, GPRC1D, MGLUR4, mGlu4 |
| バックグラウンド: | L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | mGluR4: metabotropic glutamate receptor 3, a G-protein coupled receptor for glutamate. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell development/differentiation; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 3 Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: presynaptic membrane; integral to plasma membrane; plasma membrane; terminal button; presynaptic active zone membrane; intracellular; cytoplasmic vesicle; dendritic shaft Molecular Function:calmodulin binding; G-protein coupled receptor activity; group III metabotropic glutamate receptor activity; glutamate receptor activity; calcium-dependent protein binding Biological Process: synaptic transmission; regulation of synaptic transmission, glutamatergic; positive regulation of MAPKKK cascade; activation of MAPK activity; neurotransmitter secretion; regulation of neuron apoptosis; learning; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway |
| NCBI Summary: | L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] |
| UniProt Code: | Q14833 |
| NCBI GenInfo Identifier: | 2495077 |
| NCBI Gene ID: | 2914 |
| NCBI Accession: | Q14833.1 |
| UniProt Secondary Accession: | Q14833,Q5SZ84, Q6ZMQ2, B3KVL9, B7Z1T9, B7Z1U6, F5GXM5 |
| UniProt Related Accession: | Q14833,AAB34891 |
| Molecular Weight: | |
| NCBI Full Name: | Metabotropic glutamate receptor 4 |
| NCBI Synonym Full Names: | glutamate receptor, metabotropic 4 |
| NCBI Official Symbol: | GRM4 |
| NCBI Official Synonym Symbols: | mGlu4; GPRC1D; MGLUR4 |
| NCBI Protein Information: | metabotropic glutamate receptor 4 |
| UniProt Protein Name: | Metabotropic glutamate receptor 4 |
| Protein Family: | Metabotropic glutamate receptor |
| UniProt Gene Name: | GRM4 |
| UniProt Entry Name: | GRM4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GRM4 antibody (CAB7284) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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